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10.1016/j.jcrc.2016.09.029 http://scihub22266oqcxt.onion/10.1016/j.jcrc.2016.09.029 C5328797!5328797!27866110     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Crit+Care 2017 ; 38 (ä): 84-91 Nephropedia Template TP {{tp|p=27866110|t=2017. Dysbiosis in the ICU: Microbiome science coming to the bedside |pdf=|usr=}}{{27866110}} gab.com Text Dysbiosis in the ICU: Microbiome science coming to the bedside JO: J Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=27866110 #FOAvip Complex microbial communities within the human body, constituting the microbiome, have a broad impact on human health and disease. A growing body of research now examines the role of the microbiome in patients with critical illness, such as sepsis and acute respiratory failure. In this article, we provide an introduction to microbiome concepts and terminology and we systematically review the current evidence base of the critical-illness microbiome, including 51 studies in animal models and pediatric and adult critically-ill patients. We further examine how this emerging scientific discipline may transform the way we manage infectious and inflammatory diseases in intensive care units. The evolving molecular, culture-independent techniques offer the ability to study microbial communities in unprecedented depth and detail, and in the short-term, may enable us to diagnose and treat infections in critical care more precisely and effectively. Longer-term, these tools may also give us insights in the underlying pathophysiology of critical illness and reveal previously unsuspected targets for innovative, microbiome-targeted therapeutics. We finally propose a roadmap for future studies in the field for transforming critical care from its current isolated focus on the host to a more personalized paradigm addressing both human and microbial contributions to critical illness. Twit Text FOAVip Dysbiosis in the ICU: Microbiome science coming to the bedside ????J Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=27866110 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27866110 #FOAvip English Wikipedia <ref>{{Cite pmid|27866110}}</ref> Dysbiosis in the ICU: Microbiome science coming to the bedside #MMPMID27866110 Kitsios GD; Morowitz MJ; Dickson RP; Huffnagle GB; McVerry BJ; Morris A J Crit Care 2017[Apr]; 38 (ä): 84-91 PMID27866110show ga Complex microbial communities within the human body, constituting the microbiome, have a broad impact on human health and disease. A growing body of research now examines the role of the microbiome in patients with critical illness, such as sepsis and acute respiratory failure. In this article, we provide an introduction to microbiome concepts and terminology and we systematically review the current evidence base of the critical-illness microbiome, including 51 studies in animal models and pediatric and adult critically-ill patients. We further examine how this emerging scientific discipline may transform the way we manage infectious and inflammatory diseases in intensive care units. The evolving molecular, culture-independent techniques offer the ability to study microbial communities in unprecedented depth and detail, and in the short-term, may enable us to diagnose and treat infections in critical care more precisely and effectively. Longer-term, these tools may also give us insights in the underlying pathophysiology of critical illness and reveal previously unsuspected targets for innovative, microbiome-targeted therapeutics. We finally propose a roadmap for future studies in the field for transforming critical care from its current isolated focus on the host to a more personalized paradigm addressing both human and microbial contributions to critical illness. äDysbiosis in the ICU: Microbiome science coming to the bedside (epmc).pdf DeepDyve Pubget Overpricing