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10.14814/phy2.13139 http://scihub22266oqcxt.onion/10.14814/phy2.13139 C5328774!5328774 !28242823     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28242823 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Physiol+Rep 2017 ; 5 (4 ): ä Nephropedia Template TP {{tp|p=28242823 |t=2017. Renal sympathetic nerve activity and vascular reactivity to phenylephrine after lipopolysaccharide administration in conscious rats |pdf=|usr=}}{{28242823 }} gab.com Text Renal sympathetic nerve activity and vascular reactivity to phenylephrine after lipopolysaccharide administration in conscious rats JO: Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=28242823 #FOAvip It has been proposed that sympathoexcitation is responsible for vascular desensitization to ?(1)-adrenoceptor stimulation during lipopolysaccharide (LPS)-induced systemic inflammation. The present study tested this hypothesis by examining the effects of sympatho-deactivation with the ?(2)-adrenoceptor agonist, dexmedetomidine, on mean arterial pressure (MAP), renal sympathetic nerve activity (RSNA), and vascular reactivity to phenylephrine in conscious rats with cardiac autonomic blockade (methylatropine and atenolol) following LPS administration. In male, adult Sprague-Dawley rats (n = 5 per group), RSNA and MAP were continuously recorded over 1-h periods, before and after LPS administration (20 mg/kg iv), and finally after infusion of either saline or dexmedetomidine (5 ?g/kg, then 5 ?g/kg/h iv). A full dose-response curve to phenylephrine was constructed under each condition. After pooling data from both groups of rats (n = 10), LPS significantly (P = 0.005) decreased MAP (from 115 ± 1 to 107 ± 2 mmHg), increased RSNA (to 403 ± 46% of baseline values) and induced 4 to 5-fold increases in the half-maximal effective dose (ED(50)) of phenylephrine (from 1.02 ± 0.09 to 4.76 ± 0.51 ?g/kg). During saline infusion, RSNA progressively decreased while vascular reactivity did not improve. Treatment with dexmedetomidine decreased MAP, returned RSNA to near pre-endotoxemic levels, but only partially restored vascular reactivity to phenylephrine (ED(50) was still threefold increased as compared with baseline values). These findings indicate that only part of the decrease in vascular reactivity to ?(1)-adrenoceptor stimulation during endotoxemia can be accounted for by sympathetic activation, at least on a short-term basis. Twit Text FOAVip Renal sympathetic nerve activity and vascular reactivity to phenylephrine after lipopolysaccharide administration in conscious rats ????Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=28242823 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28242823 #FOAvip English Wikipedia <ref>{{Cite pmid|28242823 }}</ref> Renal sympathetic nerve activity and vascular reactivity to phenylephrine after lipopolysaccharide administration in conscious rats #MMPMID28242823 Julien C ; Oréa V ; Quintin L ; Piriou V ; Barrès C Physiol Rep 2017[Feb]; 5 (4 ): ä PMID28242823 show ga It has been proposed that sympathoexcitation is responsible for vascular desensitization to ?(1)-adrenoceptor stimulation during lipopolysaccharide (LPS)-induced systemic inflammation. The present study tested this hypothesis by examining the effects of sympatho-deactivation with the ?(2)-adrenoceptor agonist, dexmedetomidine, on mean arterial pressure (MAP), renal sympathetic nerve activity (RSNA), and vascular reactivity to phenylephrine in conscious rats with cardiac autonomic blockade (methylatropine and atenolol) following LPS administration. In male, adult Sprague-Dawley rats (n = 5 per group), RSNA and MAP were continuously recorded over 1-h periods, before and after LPS administration (20 mg/kg iv), and finally after infusion of either saline or dexmedetomidine (5 ?g/kg, then 5 ?g/kg/h iv). A full dose-response curve to phenylephrine was constructed under each condition. After pooling data from both groups of rats (n = 10), LPS significantly (P = 0.005) decreased MAP (from 115 ± 1 to 107 ± 2 mmHg), increased RSNA (to 403 ± 46% of baseline values) and induced 4 to 5-fold increases in the half-maximal effective dose (ED(50)) of phenylephrine (from 1.02 ± 0.09 to 4.76 ± 0.51 ?g/kg). During saline infusion, RSNA progressively decreased while vascular reactivity did not improve. Treatment with dexmedetomidine decreased MAP, returned RSNA to near pre-endotoxemic levels, but only partially restored vascular reactivity to phenylephrine (ED(50) was still threefold increased as compared with baseline values). These findings indicate that only part of the decrease in vascular reactivity to ?(1)-adrenoceptor stimulation during endotoxemia can be accounted for by sympathetic activation, at least on a short-term basis. |Adrenergic alpha-1 Receptor Agonists/*pharmacology [MESH] |Animals [MESH] |Arterial Pressure/*drug effects [MESH] |Heart Rate/*drug effects [MESH] |Kidney/*innervation [MESH] |Lipopolysaccharides/*pharmacology [MESH] |Male [MESH] |Phenylephrine/*pharmacology [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH]Renal sympathetic nerve activity and vascular reactivity to phenylephr(epmc).pdf DeepDyve Pubget Overpricing