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2017 ; 61
(1
): 1264713
Nephropedia Template TP
gab.com Text
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English Wikipedia
Natural sea salt consumption confers protection against hypertension and kidney
damage in Dahl salt-sensitive rats
#MMPMID28325999
Lee BH
; Yang AR
; Kim MY
; McCurdy S
; Boisvert WA
Food Nutr Res
2017[]; 61
(1
): 1264713
PMID28325999
show ga
Although sea salts are widely available to consumers nowadays, whether its
consumption over refined salt has any real health benefits is largely unknown.
This study was conducted to compare hypertension-inducing propensity of natural
sea salt (SS) to refined salt (RS) in a well-established animal model of
hypertension. Five groups of male Dahl salt-sensitive rats were fed rat chow diet
supplemented with various amounts of salt for 15 weeks. The groups were: control
(CON, n = 10), 4% RS (RS4), 4% SS (SS4), 8% RS (RS8), 8% SS (SS8) (n = 12 for
each group). After 15 weeks, both SS4 and SS8 groups had significantly lower
systolic (SBP) and diastolic blood pressure (DBP) compared to RS4 and RS8 rats,
respectively. RS8 rats had markedly higher SBP and DBP compared to all other
groups. Echocardiography just prior to sacrifice showed abnormalities in RS4, SS8
and RS8 hearts, while CON and SS4 hearts displayed normal measurements. Plasma
renin and aldosterone levels of high salt groups were lower than those of CON,
and serum electrolytes were similar amongst all groups. Abnormal kidney pathology
and high glomerulosclerosis index scores were seen in RS4 and RS8 rats, but SS4
and SS8 kidneys showed relatively normal morphology similar to CON kidneys. Our
findings show that consumption of natural sea salt induces less hypertension
compared to refined salt in the Dahl salt-sensitive rat.