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10.1681/ASN.2016040486 http://scihub22266oqcxt.onion/10.1681/ASN.2016040486 C5328164!5328164!27612997     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27612997&cmd=llinks): Failed to open stream: HTTP request failed! 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Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease |pdf=|usr=}}{{27612997}} gab.com Text Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=27612997 #FOAvip Intrarenal crystals trigger inflammation and renal cell necroptosis, processes that involve TNF receptor (TNFR) signaling. Here, we tested the hypothesis that TNFRs also have a direct role in tubular crystal deposition and progression of hyperoxaluria-related CKD. Immunohistochemical analysis revealed upregulated tubular expression of TNFR1 and TNFR2 in human and murine kidneys with calcium oxalate (CaOx) nephrocalcinosis-related CKD compared with controls. Western blot and mRNA expression analyses in mice yielded consistent data. When fed an oxalate-rich diet, wild-type mice developed progressive CKD, whereas Tnfr1-, Tnfr2-, and Tnfr1/2-deficient mice did not. Despite identical levels of hyperoxaluria, Tnfr1-, Tnfr2-, and Tnfr1/2-deficient mice also lacked the intrarenal CaOx deposition and tubular damage observed in wild-type mice. Inhibition of TNFR signaling prevented the induced expression of the crystal adhesion molecules, CD44 and annexin II, in tubular epithelial cells in vitro and in vivo, and treatment with the small molecule TNFR inhibitor R-7050 partially protected hyperoxaluric mice from nephrocalcinosis and CKD. We conclude that TNFR signaling is essential for CaOx crystal adhesion to the luminal membrane of renal tubules as a fundamental initiating mechanism of oxalate nephropathy. Furthermore, therapeutic blockade of TNFR might delay progressive forms of nephrocalcinosis in oxalate nephropathy, such as primary hyperoxaluria. Twit Text FOAVip Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=27612997 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27612997 #FOAvip English Wikipedia <ref>{{Cite pmid|27612997}}</ref> Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease #MMPMID27612997 Mulay SR; Eberhard JN; Desai J; Marschner JA; Kumar SV; Weidenbusch M; Grigorescu M; Lech M; Eltrich N; Müller L; Hans W; Hrab? de Angelis M; Vielhauer V; Hoppe B; Asplin J; Burzlaff N; Herrmann M; Evan A; Anders HJ J Am Soc Nephrol 2017[Mar]; 28 (3): 761-8 PMID27612997show ga Intrarenal crystals trigger inflammation and renal cell necroptosis, processes that involve TNF receptor (TNFR) signaling. Here, we tested the hypothesis that TNFRs also have a direct role in tubular crystal deposition and progression of hyperoxaluria-related CKD. Immunohistochemical analysis revealed upregulated tubular expression of TNFR1 and TNFR2 in human and murine kidneys with calcium oxalate (CaOx) nephrocalcinosis-related CKD compared with controls. Western blot and mRNA expression analyses in mice yielded consistent data. When fed an oxalate-rich diet, wild-type mice developed progressive CKD, whereas Tnfr1-, Tnfr2-, and Tnfr1/2-deficient mice did not. Despite identical levels of hyperoxaluria, Tnfr1-, Tnfr2-, and Tnfr1/2-deficient mice also lacked the intrarenal CaOx deposition and tubular damage observed in wild-type mice. Inhibition of TNFR signaling prevented the induced expression of the crystal adhesion molecules, CD44 and annexin II, in tubular epithelial cells in vitro and in vivo, and treatment with the small molecule TNFR inhibitor R-7050 partially protected hyperoxaluric mice from nephrocalcinosis and CKD. We conclude that TNFR signaling is essential for CaOx crystal adhesion to the luminal membrane of renal tubules as a fundamental initiating mechanism of oxalate nephropathy. Furthermore, therapeutic blockade of TNFR might delay progressive forms of nephrocalcinosis in oxalate nephropathy, such as primary hyperoxaluria. äHyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and (epmc).pdf DeepDyve Pubget Overpricing