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Association of uremic pruritus in hemodialysis patients with the number of days of high mean 24-hour particulate matter with a diameter of 2 5 ?m #MMPMID28260912
Liu MH; Chan MJ; Hsu CW; Weng CH; Yen TH; Huang WH
Ther Clin Risk Manag 2017[]; 13 (ä): 255-62 PMID28260912show ga
Uremic pruritus (UP) is a common and incapacitating symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is multifactorial and complex. Particulate matter (PM), a major air pollutant, is a mixture of particles with various chemical compositions. PM is associated with several allergic diseases, including dermatitis. To assess the role of PM (PM with a diameter of <10 ?m [PM10] and PM with a diameter of <2.5 ?m [PM2.5]) and other clinical variables in UP in patients on HD, we recruited 866 patients on maintenance HD (MHD). We analyzed the number of days of mean 24-hour PM10 ?125 ?g/m3/12 months (NDPM10) or the number of days of mean 24-hour PM2.5 ?35 ?g/m3/12 months (NDPM2.5) exceeding the standard level in the past 12 months respectively to determine the association with UP. In a multivariate logistic regression, HD duration, serum ferritin levels, low-density lipoprotein (LDL) levels, and NDPM2.5 ?116 days/12 months were positively associated with UP. This cross-sectional study showed that the number of days on which the environmental PM2.5 exceeds the standard level might be associated with UP in patients on MHD.