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10.1155/2017/5364827 http://scihub22266oqcxt.onion/10.1155/2017/5364827 C5327787!5327787!28286691     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Scientifica+(Cairo) 2017 ; 2017 (ä): ä Nephropedia Template TP {{tp|p=28286691|t=2017. Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans |pdf=|usr=}}{{28286691}} gab.com Text Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans JO: Scientifica (Cairo) http://www.kidney.de/pget.php?&tw=1&pmid=28286691 #FOAvip Spina bifida is among the phenotypes of the larger condition known as neural tube defects (NTDs). It is the most common central nervous system malformation compatible with life and the second leading cause of birth defects after congenital heart defects. In this review paper, we define spina bifida and discuss the phenotypes seen in humans as described by both surgeons and embryologists in order to compare and ultimately contrast it to the leading animal model, the mouse. Our understanding of spina bifida is currently limited to the observations we make in mouse models, which reflect complete or targeted knockouts of genes, which perturb the whole gene(s) without taking into account the issue of haploinsufficiency, which is most prominent in the human spina bifida condition. We thus conclude that the need to study spina bifida in all its forms, both aperta and occulta, is more indicative of the spina bifida in surviving humans and that the measure of deterioration arising from caudal neural tube defects, more commonly known as spina bifida, must be determined by the level of the lesion both in mouse and in man. Twit Text FOAVip Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans ????Scientifica (Cairo) http://www.kidney.de/pget.php?&tw=1&pmid=28286691 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28286691 #FOAvip English Wikipedia <ref>{{Cite pmid|28286691}}</ref> Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans #MMPMID28286691 Mohd-Zin SW; Marwan AI; Abou Chaar MK; Ahmad-Annuar A; Abdul-Aziz NM Scientifica (Cairo) 2017[]; 2017 (ä): ä PMID28286691show ga Spina bifida is among the phenotypes of the larger condition known as neural tube defects (NTDs). It is the most common central nervous system malformation compatible with life and the second leading cause of birth defects after congenital heart defects. In this review paper, we define spina bifida and discuss the phenotypes seen in humans as described by both surgeons and embryologists in order to compare and ultimately contrast it to the leading animal model, the mouse. Our understanding of spina bifida is currently limited to the observations we make in mouse models, which reflect complete or targeted knockouts of genes, which perturb the whole gene(s) without taking into account the issue of haploinsufficiency, which is most prominent in the human spina bifida condition. We thus conclude that the need to study spina bifida in all its forms, both aperta and occulta, is more indicative of the spina bifida in surviving humans and that the measure of deterioration arising from caudal neural tube defects, more commonly known as spina bifida, must be determined by the level of the lesion both in mouse and in man. äSpina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans (epmc).pdf DeepDyve Pubget Overpricing