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Metabolic pattern formation in the tumor microenvironment #MMPMID28183842
Dai Z; Locasale JW
Mol Syst Biol 2017[Feb]; 13 (2): ä PMID28183842show ga
Metabolic alterations including increased glycolysis are a common feature of many cancers. In their recent study, Lowengrub, Waterman, and colleagues (Lee et al, 2017) report a spatial pattern of glycolysis in solid tumors that occurs within the tumor microenvironment. This spatial organization is linked to gradients derived from Wnt signaling and nutrient availability that mediate a reaction?diffusion mechanism and is consistent with a Turing?type model of spatial localization.