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10.1186/s40560-017-0217-0 http://scihub22266oqcxt.onion/10.1186/s40560-017-0217-0 C5327570!5327570 !28261486     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28261486 &cmd=llinks): Failed to open stream: HTTP request failed! 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Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis |pdf=|usr=}}{{28261486 }} gab.com Text Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis JO: J Intensive Care http://www.kidney.de/pget.php?&tw=1&pmid=28261486 #FOAvip BACKGROUND: Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, mostly affects young people and causes high mortality. This study aimed to investigate the effect of targeting two key molecules of innate immunity, complement component C5, and co-receptor CD14 in the Toll-like receptor system, on the inflammatory response in meningococcal sepsis. METHODS: Meningococcal sepsis was simulated by continuous intravenous infusion of an escalating dose of heat-inactivated Neisseria meningitidis administered over 3 h. The piglets were randomized, blinded to the investigators, to a positive control group (n?=?12) receiving saline and to an interventional group (n?=?12) receiving a recombinant anti-CD14 monoclonal antibody together with the C5 inhibitor coversin. RESULTS: A substantial increase in plasma complement activation in the untreated group was completely abolished in the treatment group (p?=?0.006). The following inflammatory mediators were substantially reduced in plasma in the treatment group: Interferon-? by 75% (p?=?0.0001), tumor necrosis factor by 50% (p?=?0.01), Interleukin (IL)-8 by 50% (p?=?0.03), IL-10 by 40% (p?=?0.04), IL-12p40 by 50% (p?=?0.03), and granulocyte CD11b (CR3) expression by 20% (p?=?0.01). CONCLUSION: Inhibition of C5 and CD14 may be beneficial in attenuating the detrimental effects of complement activation and modulating the cytokine storm in patients with fulminant meningococcal sepsis. Twit Text FOAVip Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis ????J Intensive Care http://www.kidney.de/pget.php?&tw=1&pmid=28261486 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28261486 #FOAvip English Wikipedia <ref>{{Cite pmid|28261486 }}</ref> Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis #MMPMID28261486 Hellerud BC ; Orrem HL ; Dybwik K ; Pischke SE ; Baratt-Due A ; Castellheim A ; Fure H ; Bergseth G ; Christiansen D ; Nunn MA ; Espevik T ; Lau C ; Brandtzęg P ; Nielsen EW ; Mollnes TE J Intensive Care 2017[]; 5 (ä): 21 PMID28261486 show ga BACKGROUND: Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, mostly affects young people and causes high mortality. This study aimed to investigate the effect of targeting two key molecules of innate immunity, complement component C5, and co-receptor CD14 in the Toll-like receptor system, on the inflammatory response in meningococcal sepsis. METHODS: Meningococcal sepsis was simulated by continuous intravenous infusion of an escalating dose of heat-inactivated Neisseria meningitidis administered over 3 h. The piglets were randomized, blinded to the investigators, to a positive control group (n?=?12) receiving saline and to an interventional group (n?=?12) receiving a recombinant anti-CD14 monoclonal antibody together with the C5 inhibitor coversin. RESULTS: A substantial increase in plasma complement activation in the untreated group was completely abolished in the treatment group (p?=?0.006). The following inflammatory mediators were substantially reduced in plasma in the treatment group: Interferon-? by 75% (p?=?0.0001), tumor necrosis factor by 50% (p?=?0.01), Interleukin (IL)-8 by 50% (p?=?0.03), IL-10 by 40% (p?=?0.04), IL-12p40 by 50% (p?=?0.03), and granulocyte CD11b (CR3) expression by 20% (p?=?0.01). CONCLUSION: Inhibition of C5 and CD14 may be beneficial in attenuating the detrimental effects of complement activation and modulating the cytokine storm in patients with fulminant meningococcal sepsis. äCombined inhibition of C5 and CD14 efficiently attenuated the inflamma(epmc).pdf DeepDyve Pubget Overpricing