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10.1186/s12916-017-0798-4 http://scihub22266oqcxt.onion/10.1186/s12916-017-0798-4 C5327528!5327528!28238287     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Med 2017 ; 15 (ä): ä Nephropedia Template TP {{tp|p=28238287|t=2017. Genome editing for inborn errors of metabolism: advancing towards the clinic |pdf=|usr=}}{{28238287}} gab.com Text Genome editing for inborn errors of metabolism: advancing towards the clinic JO: BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=28238287 #FOAvip Inborn errors of metabolism (IEM) include many disorders for which current treatments aim to ameliorate disease manifestations, but are not curative. Advances in the field of genome editing have recently resulted in the in vivo correction of murine models of IEM. Site-specific endonucleases, such as zinc-finger nucleases and the CRISPR/Cas9 system, in combination with delivery vectors engineered to target disease tissue, have enabled correction of mutations in disease models of hemophilia B, hereditary tyrosinemia type I, ornithine transcarbamylase deficiency, and lysosomal storage disorders. These in vivo gene correction studies, as well as an overview of genome editing and future directions for the field, are reviewed and discussed herein. Twit Text FOAVip Genome editing for inborn errors of metabolism: advancing towards the clinic ????BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=28238287 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28238287 #FOAvip English Wikipedia <ref>{{Cite pmid|28238287}}</ref> Genome editing for inborn errors of metabolism: advancing towards the clinic #MMPMID28238287 Schneller JL; Lee CM; Bao G; Venditti CP BMC Med 2017[]; 15 (ä): ä PMID28238287show ga Inborn errors of metabolism (IEM) include many disorders for which current treatments aim to ameliorate disease manifestations, but are not curative. Advances in the field of genome editing have recently resulted in the in vivo correction of murine models of IEM. Site-specific endonucleases, such as zinc-finger nucleases and the CRISPR/Cas9 system, in combination with delivery vectors engineered to target disease tissue, have enabled correction of mutations in disease models of hemophilia B, hereditary tyrosinemia type I, ornithine transcarbamylase deficiency, and lysosomal storage disorders. These in vivo gene correction studies, as well as an overview of genome editing and future directions for the field, are reviewed and discussed herein. äGenome editing for inborn errors of metabolism: advancing towards the (epmc).pdf DeepDyve Pubget Overpricing