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10.1038/srep43441 http://scihub22266oqcxt.onion/10.1038/srep43441 C5327488!5327488 !28240310     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28240310 &cmd=llinks): Failed to open stream: HTTP request failed! 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Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47(phox) |pdf=|usr=}}{{28240310 }} gab.com Text Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47(phox) JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28240310 #FOAvip Interleukin (IL)-27, a member of the IL-12 cytokine family, plays an important and diverse role in the function of the immune system. We have previously demonstrated that IL-27 is an anti-viral cytokine which inhibits HIV-1, HIV-2, Influenza virus and herpes simplex virus infection, and enhances the potential of reactive oxygen species (ROS) generating activity during differentiation of monocytes to macrophages. In this study, we further investigated the mechanism of the enhanced potential for ROS generation by IL-27. Real time PCR, western blot and knock down assays demonstrate that IL-27 is able to enhance the potential of superoxide production not only during differentiation but also in terminally differentiated-macrophages and immature dendritic cells (iDC) in association with the induction of p47(phox), a cytosolic component of the ROS producing enzyme, NADPH oxidase, and the increase in amounts of phosphorylated p47(phox) upon stimulation. We also demonstrate that IL-27 is able to induce extracellular superoxide dismutase during differentiation of monocytes but not in terminal differentiated macrophages. Since ROS plays an important role in a variety of inflammation, our data demonstrate that IL-27 is a potent regulator of ROS induction and may be a novel therapeutic target. Twit Text FOAVip Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47(phox) ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28240310 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28240310 #FOAvip English Wikipedia <ref>{{Cite pmid|28240310 }}</ref> Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47(phox) #MMPMID28240310 Sowrirajan B ; Saito Y ; Poudyal D ; Chen Q ; Sui H ; DeRavin SS ; Imamichi H ; Sato T ; Kuhns DB ; Noguchi N ; Malech HL ; Lane HC ; Imamichi T Sci Rep 2017[Feb]; 7 (ä): 43441 PMID28240310 show ga Interleukin (IL)-27, a member of the IL-12 cytokine family, plays an important and diverse role in the function of the immune system. We have previously demonstrated that IL-27 is an anti-viral cytokine which inhibits HIV-1, HIV-2, Influenza virus and herpes simplex virus infection, and enhances the potential of reactive oxygen species (ROS) generating activity during differentiation of monocytes to macrophages. In this study, we further investigated the mechanism of the enhanced potential for ROS generation by IL-27. Real time PCR, western blot and knock down assays demonstrate that IL-27 is able to enhance the potential of superoxide production not only during differentiation but also in terminally differentiated-macrophages and immature dendritic cells (iDC) in association with the induction of p47(phox), a cytosolic component of the ROS producing enzyme, NADPH oxidase, and the increase in amounts of phosphorylated p47(phox) upon stimulation. We also demonstrate that IL-27 is able to induce extracellular superoxide dismutase during differentiation of monocytes but not in terminal differentiated macrophages. Since ROS plays an important role in a variety of inflammation, our data demonstrate that IL-27 is a potent regulator of ROS induction and may be a novel therapeutic target. |Cell Differentiation/drug effects [MESH] |Dendritic Cells/cytology/*drug effects/immunology [MESH] |Gene Expression Regulation [MESH] |Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology [MESH] |Humans [MESH] |Interleukin-4/pharmacology [MESH] |Interleukins/*pharmacology [MESH] |Macrophage Activation/drug effects [MESH] |Macrophage Colony-Stimulating Factor/pharmacology [MESH] |Macrophages/cytology/*drug effects/immunology [MESH] |NADPH Oxidases/*genetics/immunology [MESH] |Phosphorylation/drug effects [MESH] |Primary Cell Culture [MESH] |Signal Transduction [MESH] |Superoxide Dismutase/genetics/immunology [MESH]Interleukin-27 Enhances the Potential of Reactive Oxygen Species Gener(epmc).pdf DeepDyve Pubget Overpricing