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10.3389/fimmu.2017.00200 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.00200 C5327443!5327443!28289419     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28289419|t=2017. Cytokine Signatures in Mucocutaneous and Ocular Behçet?s Disease |pdf=|usr=}}{{28289419}} gab.com Text Cytokine Signatures in Mucocutaneous and Ocular Behçet s Disease JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28289419 #FOAvip Behçet?s disease (BD) is a multi-systemic inflammatory disorder consisting of recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis; however, many other organs may be affected. Several pro-inflammatory cytokines, mainly derived from Th1 and Th17 lymphocytes, seem to be involved in different pathogenic pathways leading to development of the clinical manifestations. On this basis, the primary aim of our study was to compare a core set of pro-inflammatory cytokines between patients with BD and healthy control (HC). The secondary goal was to evaluate potential correlations between these putative circulating biomarkers, the status of disease activity, and the specific organ involvement at the time of sample collection. Fifty-four serum samples were collected from 46 BD patients (17 males, 29 females, mean age 45.5?±?11.3?years), and 19 HC (10 males, 9 females, mean age 43?±?8.3?years). Twenty-five serum cytokines (APRIL/TNFS13, BAFF/TNFSF13B, sCD30/TNFRSF8, sCD163, Chitinase3-like1, gp130/sIL-6Rb, IFNb, sIL-6Ra, IL-10, IL-11, IL-19, IL-20, IL-26, IL-27 (p28), IL-28A/IFN-lambda2, IL-29/IFN-lambda1, IL-32, IL-34, IL-35, LIGHT/TNFSF-14, Pentraxin-3, sTNF-R1, sTNF-R2, TSLP, and TWEAK/TNFSF-12) were simultaneously quantified using a Bio-Rad cytokine bead arrays. Serum concentration of sTNF-R1 (p?<?0.01) and sTNF-R2 (p?<?0.01) resulted higher in both active and inactive BD than HC, while Chitinase3-like1 (p?<?0.05) and gp130/sIL-6Rb (p?<?0.01) serum levels were significantly higher in inactive BD, and IL-26 (p?<?0.01) in active BD than HC. No differences were observed between inactive and active BD group. In addition, we observed that gp130/sIL-6Rb, sIL-6Ra, IL-35, and TSLP serum levels were significantly enhanced in patients with mucocutaneous manifestations plus ocular involvement (MO-BD) compared to subgroup with only mucocutaneous involvement (M-BD). Our findings may suggest a signature of IL-6, tumor necrosis factor-? as well as of Th17 response in BD patients due to increased levels of gp130/sIL-6Rb, sTNF-R1, sTNF-R2, IL-26, respectively. This evidence could contribute to improve the knowledge regarding the role of these citokines in the induction of specific BD clinical features. Twit Text FOAVip Cytokine Signatures in Mucocutaneous and Ocular Behçet s Disease ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28289419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28289419 #FOAvip English Wikipedia <ref>{{Cite pmid|28289419}}</ref> Cytokine Signatures in Mucocutaneous and Ocular Behçet?s Disease #MMPMID28289419 Lopalco G; Lucherini OM; Lopalco A; Venerito V; Fabiani C; Frediani B; Galeazzi M; Lapadula G; Cantarini L; Iannone F Front Immunol 2017[]; 8 (ä): ä PMID28289419show ga Behçet?s disease (BD) is a multi-systemic inflammatory disorder consisting of recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis; however, many other organs may be affected. Several pro-inflammatory cytokines, mainly derived from Th1 and Th17 lymphocytes, seem to be involved in different pathogenic pathways leading to development of the clinical manifestations. On this basis, the primary aim of our study was to compare a core set of pro-inflammatory cytokines between patients with BD and healthy control (HC). The secondary goal was to evaluate potential correlations between these putative circulating biomarkers, the status of disease activity, and the specific organ involvement at the time of sample collection. Fifty-four serum samples were collected from 46 BD patients (17 males, 29 females, mean age 45.5?±?11.3?years), and 19 HC (10 males, 9 females, mean age 43?±?8.3?years). Twenty-five serum cytokines (APRIL/TNFS13, BAFF/TNFSF13B, sCD30/TNFRSF8, sCD163, Chitinase3-like1, gp130/sIL-6Rb, IFNb, sIL-6Ra, IL-10, IL-11, IL-19, IL-20, IL-26, IL-27 (p28), IL-28A/IFN-lambda2, IL-29/IFN-lambda1, IL-32, IL-34, IL-35, LIGHT/TNFSF-14, Pentraxin-3, sTNF-R1, sTNF-R2, TSLP, and TWEAK/TNFSF-12) were simultaneously quantified using a Bio-Rad cytokine bead arrays. Serum concentration of sTNF-R1 (p? äCytokine Signatures in Mucocutaneous and Ocular Behçet?s Disease (epmc).pdf DeepDyve Pubget Overpricing