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2017 ; 7
(ä): 43303
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Association of Renal Elasticity and Renal Function Progression in Patients with
Chronic Kidney Disease Evaluated by Real-Time Ultrasound Elastography
#MMPMID28240304
Lin HY
; Lee YL
; Lin KD
; Chiu YW
; Shin SJ
; Hwang SJ
; Chen HC
; Hung CC
Sci Rep
2017[Feb]; 7
(ä): 43303
PMID28240304
show ga
Glomerulosclerosis and tubulointerstitial fibrosis are associated with lower
renal parenchymal elasticity. This study was designed to evaluate the predictive
ability of renal elasticity in patients with chronic kidney disease (CKD). 148
non-CKD patients and 227 patients with CKD were recruited. 145 (38.7%) were
female, 166 (73.1%) had diabetes, the mean estimated glomerular filtration rate
(eGFR) was 33.9?±?15.8?ml/min/1.73?m(2) and the median urinary
protein-to-creatinine ratio (UPCR) 502 (122-1491)?mg/g. Patients with later
stages of CKD had lower renal elasticity values, indicating stiffer kidneys
(p?0.001), and smaller kidney (p?0.001). Renal elasticity correlated with
log-transformed UPCR (??=?-7.544, P?0.001). Renal length correlated with age
(??=?-0.231, P?0.001), sex (??=?-3.730, P?0.001), serum albumin level
(??=?-3.024, P?=?0.001), body mass index (??=?0.390, P?=?0.009) and eGFR
(??=?0.146, P?0.001). In fully-adjusted logistic regression model, the odds
ratio (OR) per 10 unit change in renal elasticity for rapid renal deterioration
was 0.928 (95% CI, 0.864-0.997; P?=?0.042). The OR per 1?mm change in renal
length for rapid renal deterioration was 1.022 (95% CI, 0.994-1.050; P?=?0.125).
Renal elasticity is associated with proteinuria and rapid renal deterioration in
patients with CKD.