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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Theranostics 2017 ; 7 (2): 425-35 Nephropedia Template TP
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Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action #MMPMID28255340
Ai Xy; Liu Hj; Lu C; Liang Cl; Sun Y; Chen S; Sun B; Li Y; Liu Yr; Zhang Q; Liu Xq; Xiao T; Jing Xs; Sun T; Zhou Hg; Yang C
Theranostics 2017[]; 7 (2): 425-35 PMID28255340show ga
Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies showed that PnAg could accelerate dermal wound healing and strong inflammation control in Sprague-Dawley rats (SD rat) and Bama minipigs. Due to its low solubility, PnAg led to low toxicity and blood enrichment in animals. Furthermore, PnAg could upregulate the promoter activity of Jak, Stat3, and Stat3 downstream proteins. Therefore, PnAg may serve as an effective therapeutic compound for wound healing through regulating the gp130/Jak/Stat3 signaling pathway.