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10.7150/thno.17073 http://scihub22266oqcxt.onion/10.7150/thno.17073 C5327358!5327358 !28255340     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28255340 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Theranostics 2017 ; 7 (2 ): 425-435 Nephropedia Template TP {{tp|p=28255340 |t=2017. Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action |pdf=|usr=}}{{28255340 }} gab.com Text Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action JO: Theranostics http://www.kidney.de/pget.php?&tw=1&pmid=28255340 #FOAvip Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies showed that PnAg could accelerate dermal wound healing and strong inflammation control in Sprague-Dawley rats (SD rat) and Bama minipigs. Due to its low solubility, PnAg led to low toxicity and blood enrichment in animals. Furthermore, PnAg could upregulate the promoter activity of Jak, Stat3, and Stat3 downstream proteins. Therefore, PnAg may serve as an effective therapeutic compound for wound healing through regulating the gp130/Jak/Stat3 signaling pathway. Twit Text FOAVip Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action ????Theranostics http://www.kidney.de/pget.php?&tw=1&pmid=28255340 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28255340 #FOAvip English Wikipedia <ref>{{Cite pmid|28255340 }}</ref> Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action #MMPMID28255340 Ai XY ; Liu HJ ; Lu C ; Liang CL ; Sun Y ; Chen S ; Sun B ; Li Y ; Liu YR ; Zhang Q ; Liu XQ ; Xiao T ; Jing XS ; Sun T ; Zhou HG ; Yang C Theranostics 2017[]; 7 (2 ): 425-435 PMID28255340 show ga Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies showed that PnAg could accelerate dermal wound healing and strong inflammation control in Sprague-Dawley rats (SD rat) and Bama minipigs. Due to its low solubility, PnAg led to low toxicity and blood enrichment in animals. Furthermore, PnAg could upregulate the promoter activity of Jak, Stat3, and Stat3 downstream proteins. Therefore, PnAg may serve as an effective therapeutic compound for wound healing through regulating the gp130/Jak/Stat3 signaling pathway. |Animals [MESH] |Anti-Infective Agents, Local/*administration & dosage [MESH] |Cytokine Receptor gp130/agonists [MESH] |Disease Models, Animal [MESH] |Immunologic Factors/*administration & dosage [MESH] |Janus Kinases/metabolism [MESH] |Nanostructures/*administration & dosage [MESH] |Phenytoin/*administration & dosage [MESH] |Rats, Sprague-Dawley [MESH] |STAT3 Transcription Factor/metabolism [MESH] |Signal Transduction [MESH] |Silver/*administration & dosage [MESH] |Swine [MESH] |Swine, Miniature [MESH] |Treatment Outcome [MESH] |Wound Healing/*drug effects [MESH]Phenytoin silver: a new nanocompound for promoting dermal wound healin(epmc).pdf DeepDyve Pubget Overpricing