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10.1016/bs.acr.2016.05.001 http://scihub22266oqcxt.onion/10.1016/bs.acr.2016.05.001 C5325795!5325795!27451124     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Cancer+Res 2016 ; 131 (ä): 59-95 Nephropedia Template TP {{tp|p=27451124|t=2016. H3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer |pdf=|usr=}}{{27451124}} gab.com Text H3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer JO: Adv Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27451124 #FOAvip Epigenetics, the modification of chromatin without changing the DNA sequence itself, determines whether a gene is expressed, and how much of a gene is expressed. Methylation of lysine 27 on histone 3 (H3K27me), a modification usually associated with gene repression, has established roles in regulating the expression of genes involved in lineage commitment and differentiation. Not surprisingly, alterations in the homeostasis of this critical mark have emerged as a recurrent theme in the pathogenesis of many cancers. Perturbations in the distribution or levels of H3K27me occur due to deregulation at all levels of the process, either by mutation in the histone itself, or changes in the activity of the writers, erasers or readers of this mark. Additionally, as no single histone mark alone determines the overall transcriptional readiness of a chromatin region, deregulation of other chromatin marks can also have dramatic consequences. Finally, the significance of mutations altering H3K27me is highlighted by the poor clinical outcome of patients whose tumors harbor such lesions. Current therapeutic approaches targeting aberrant H3K27 methylation remain to be proven useful in the clinic. Understanding the biological consequences and gene expression pathways affected by aberrant H3K27 methylation may lead to identification of new therapeutic targets and strategies. Twit Text FOAVip H3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer ????Adv Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27451124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27451124 #FOAvip English Wikipedia <ref>{{Cite pmid|27451124}}</ref> H3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer #MMPMID27451124 Nichol JN; Dupéré-Richer D; Ezponda T; Licht JD; Miller WH Adv Cancer Res 2016[]; 131 (ä): 59-95 PMID27451124show ga Epigenetics, the modification of chromatin without changing the DNA sequence itself, determines whether a gene is expressed, and how much of a gene is expressed. Methylation of lysine 27 on histone 3 (H3K27me), a modification usually associated with gene repression, has established roles in regulating the expression of genes involved in lineage commitment and differentiation. Not surprisingly, alterations in the homeostasis of this critical mark have emerged as a recurrent theme in the pathogenesis of many cancers. Perturbations in the distribution or levels of H3K27me occur due to deregulation at all levels of the process, either by mutation in the histone itself, or changes in the activity of the writers, erasers or readers of this mark. Additionally, as no single histone mark alone determines the overall transcriptional readiness of a chromatin region, deregulation of other chromatin marks can also have dramatic consequences. Finally, the significance of mutations altering H3K27me is highlighted by the poor clinical outcome of patients whose tumors harbor such lesions. Current therapeutic approaches targeting aberrant H3K27 methylation remain to be proven useful in the clinic. Understanding the biological consequences and gene expression pathways affected by aberrant H3K27 methylation may lead to identification of new therapeutic targets and strategies. äH3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer (epmc).pdf DeepDyve Pubget Overpricing