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10.1016/j.jmb.2017.01.001 http://scihub22266oqcxt.onion/10.1016/j.jmb.2017.01.001 C5325780!5325780!28104363     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Biol 2017 ; 429 (5): 633-46 Nephropedia Template TP {{tp|p=28104363|t=2017. Insights into the distinct mechanisms of action of taxane and non-taxane microtubule stabilizers from cryo-EM structures |pdf=|usr=}}{{28104363}} gab.com Text Insights into the distinct mechanisms of action of taxane and non-taxane microtubule stabilizers from cryo-EM structures JO: J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=28104363 #FOAvip A number of microtubule-stabilizing agents have demonstrated or predicted potential as anticancer agents, but a detailed structural basis for their mechanism of action is still lacking. We have obtained high-resolution (3.9 ? 4.2 Å) cryo-EM reconstructions of microtubules stabilized by the taxane-site binders Taxol and zampanolide, and by peloruside, which targets a distinct, non-taxoid pocket on ?-tubulin. We find that each molecule has unique distinct structural effects on the microtubule lattice structure. Peloruside acts primarily at lateral contacts and has an effect on the ?seam? of heterologous interactions, enforcing a conformation more similar to that of homologous (i.e. non-seam) contacts by which it regularizes the microtubule lattice. In contrast, binding of either Taxol or zampanolide induces microtubule heterogeneity. In doubly-bound microtubules, peloruside overrides the heterogeneity induced by Taxol-binding. Our structural analysis illustrates distinct mechanisms of these drugs for stabilizing the microtubule lattice, and is of relevance to the possible use of combinations of microtubule-stabilizing agents to regulate microtubules activity and improve therapeutic potential. Twit Text FOAVip Insights into the distinct mechanisms of action of taxane and non-taxane microtubule stabilizers from cryo-EM structures ????J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=28104363 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28104363 #FOAvip English Wikipedia <ref>{{Cite pmid|28104363}}</ref> Insights into the distinct mechanisms of action of taxane and non-taxane microtubule stabilizers from cryo-EM structures #MMPMID28104363 Kellogg EH; Hejab NMA; Howes S; Northcote P; Miller JH; Díaz JF; Downing KH; Nogales E J Mol Biol 2017[Mar]; 429 (5): 633-46 PMID28104363show ga A number of microtubule-stabilizing agents have demonstrated or predicted potential as anticancer agents, but a detailed structural basis for their mechanism of action is still lacking. We have obtained high-resolution (3.9 ? 4.2 Å) cryo-EM reconstructions of microtubules stabilized by the taxane-site binders Taxol and zampanolide, and by peloruside, which targets a distinct, non-taxoid pocket on ?-tubulin. We find that each molecule has unique distinct structural effects on the microtubule lattice structure. Peloruside acts primarily at lateral contacts and has an effect on the ?seam? of heterologous interactions, enforcing a conformation more similar to that of homologous (i.e. non-seam) contacts by which it regularizes the microtubule lattice. In contrast, binding of either Taxol or zampanolide induces microtubule heterogeneity. In doubly-bound microtubules, peloruside overrides the heterogeneity induced by Taxol-binding. Our structural analysis illustrates distinct mechanisms of these drugs for stabilizing the microtubule lattice, and is of relevance to the possible use of combinations of microtubule-stabilizing agents to regulate microtubules activity and improve therapeutic potential. äInsights into the distinct mechanisms of action of taxane and non-taxa(epmc).pdf DeepDyve Pubget Overpricing