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10.1016/j.virol.2016.12.019 http://scihub22266oqcxt.onion/10.1016/j.virol.2016.12.019 C5325777!5325777 !28068513     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28068513 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Virology 2017 ; 503 (ä): 1-5 Nephropedia Template TP {{tp|p=28068513 |t=2017. Nrf2-dependent induction of innate host defense via heme oxygenase-1 inhibits Zika virus replication |pdf=|usr=}}{{28068513 }} gab.com Text Nrf2-dependent induction of innate host defense via heme oxygenase-1 inhibits Zika virus replication JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=28068513 #FOAvip We identified primary human monocyte-derived macrophages (MDM) as vulnerable target cells for Zika virus (ZIKV) infection. We demonstrate dramatic effects of hemin, the natural inducer of the heme catabolic enzyme heme oxygenase-1 (HO-1), in the reduction of ZIKV replication in vitro. Both LLC-MK2 monkey kidney cells and primary MDM exhibited hemin-induced HO-1 expression with major reductions of >90% in ZIKV replication, with little toxicity to infected cells. Silencing expression of HO-1 or its upstream regulatory gene, nuclear factor erythroid-related factor 2 (Nrf2), attenuated hemin-induced suppression of ZIKV infection, suggesting an important role for induction of these intracellular mediators in retarding ZIKV replication. The inverse correlation between hemin-induced HO-1 levels and ZIKV replication provides a potentially useful therapeutic modality based on stimulation of an innate cellular response against Zika virus infection. Twit Text FOAVip Nrf2-dependent induction of innate host defense via heme oxygenase-1 inhibits Zika virus replication ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=28068513 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28068513 #FOAvip English Wikipedia <ref>{{Cite pmid|28068513 }}</ref> Nrf2-dependent induction of innate host defense via heme oxygenase-1 inhibits Zika virus replication #MMPMID28068513 Huang H ; Falgout B ; Takeda K ; Yamada KM ; Dhawan S Virology 2017[Mar]; 503 (ä): 1-5 PMID28068513 show ga We identified primary human monocyte-derived macrophages (MDM) as vulnerable target cells for Zika virus (ZIKV) infection. We demonstrate dramatic effects of hemin, the natural inducer of the heme catabolic enzyme heme oxygenase-1 (HO-1), in the reduction of ZIKV replication in vitro. Both LLC-MK2 monkey kidney cells and primary MDM exhibited hemin-induced HO-1 expression with major reductions of >90% in ZIKV replication, with little toxicity to infected cells. Silencing expression of HO-1 or its upstream regulatory gene, nuclear factor erythroid-related factor 2 (Nrf2), attenuated hemin-induced suppression of ZIKV infection, suggesting an important role for induction of these intracellular mediators in retarding ZIKV replication. The inverse correlation between hemin-induced HO-1 levels and ZIKV replication provides a potentially useful therapeutic modality based on stimulation of an innate cellular response against Zika virus infection. |Cells, Cultured [MESH] |Heme Oxygenase-1/genetics/*metabolism [MESH] |Hemin/*pharmacology [MESH] |Humans [MESH] |Immunity, Innate/immunology [MESH] |Macrophages/immunology/*virology [MESH] |NF-E2-Related Factor 2/genetics/*metabolism [MESH] |RNA Interference [MESH] |RNA, Small Interfering/genetics [MESH] |Virus Replication/*drug effects/immunology [MESH] |Zika Virus Infection/*drug therapy/virology [MESH]Nrf2-dependent induction of innate host defense via heme oxygenase-1 i(epmc).pdf DeepDyve Pubget Overpricing