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10.1016/j.gene.2016.01.006 http://scihub22266oqcxt.onion/10.1016/j.gene.2016.01.006 C5325693!5325693!26774798     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gene 2016 ; 582 (1): 1-13 Nephropedia Template TP {{tp|p=26774798|t=2016. TNNT1, TNNT2, and TNNT3: Isoform Genes, Regulation, and Structure-Function Relationships |pdf=|usr=}}{{26774798}} gab.com Text TNNT1, TNNT2, and TNNT3: Isoform Genes, Regulation, and Structure-Function Relationships JO: Gene http://www.kidney.de/pget.php?&tw=1&pmid=26774798 #FOAvip Troponin T (TnT) is a central player in the calcium regulation of actin thin filament function and is essential for the contraction of striated muscles. Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT. Alternative splicing and posttranslational modifications confer additional structural and functional variations of TnT during development and muscle adaptation to various physiological and pathological conditions. This review focuses on the TnT isoform genes and their molecular evolution, alternative splicing, developmental regulation, structure-function relationships of TnT proteins, posttranslational modifications, and myopathic mutations and abnormal splicing. The goal is to provide a concise summary of the current knowledge and some perspectives for future research and translational applications. Twit Text FOAVip TNNT1, TNNT2, and TNNT3: Isoform Genes, Regulation, and Structure-Function Relationships ????Gene http://www.kidney.de/pget.php?&tw=1&pmid=26774798 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26774798 #FOAvip English Wikipedia <ref>{{Cite pmid|26774798}}</ref> TNNT1, TNNT2, and TNNT3: Isoform Genes, Regulation, and Structure-Function Relationships #MMPMID26774798 Wei B; Jin JP Gene 2016[May]; 582 (1): 1-13 PMID26774798show ga Troponin T (TnT) is a central player in the calcium regulation of actin thin filament function and is essential for the contraction of striated muscles. Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT. Alternative splicing and posttranslational modifications confer additional structural and functional variations of TnT during development and muscle adaptation to various physiological and pathological conditions. This review focuses on the TnT isoform genes and their molecular evolution, alternative splicing, developmental regulation, structure-function relationships of TnT proteins, posttranslational modifications, and myopathic mutations and abnormal splicing. The goal is to provide a concise summary of the current knowledge and some perspectives for future research and translational applications. äTNNT1, TNNT2, and TNNT3: Isoform Genes, Regulation, and Structure-Func(epmc).pdf DeepDyve Pubget Overpricing