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10.1371/journal.ppat.1006196 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1006196 C5325592!5325592 !28192528     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28192528 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+Pathog 2017 ; 13 (2 ): e1006196 Nephropedia Template TP {{tp|p=28192528 |t=2017. CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1? production |pdf=|usr=}}{{28192528 }} gab.com Text CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1 production JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=28192528 #FOAvip Deregulated CD8+ T cell cytotoxicity plays a central role in enhancing disease severity in several conditions. However, we have little understanding of the mechanisms by which immunopathology develops as a consequence of cytotoxicity. Using murine models of inflammation induced by the protozoan parasite leishmania, and data obtained from patients with cutaneous leishmaniasis, we uncovered a previously unrecognized role for NLRP3 inflammasome activation and IL-1? release as a detrimental consequence of CD8+ T cell-mediated cytotoxicity, ultimately resulting in chronic inflammation. Critically, pharmacological blockade of NLRP3 or IL-1? significantly ameliorated the CD8+ T cell-driven immunopathology in leishmania-infected mice. Confirming the relevance of these findings to human leishmaniasis, blockade of the NLRP3 inflammasome in skin biopsies from leishmania-infected patients prevented IL-1? release. Thus, these studies link CD8+ T cell cytotoxicity with inflammasome activation and reveal novel avenues of treatment for cutaneous leishmaniasis, as well as other of diseases where CD8+ T cell-mediated cytotoxicity induces pathology. Twit Text FOAVip CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1 production ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=28192528 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28192528 #FOAvip English Wikipedia <ref>{{Cite pmid|28192528 }}</ref> CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1? production #MMPMID28192528 Novais FO ; Carvalho AM ; Clark ML ; Carvalho LP ; Beiting DP ; Brodsky IE ; Carvalho EM ; Scott P PLoS Pathog 2017[Feb]; 13 (2 ): e1006196 PMID28192528 show ga Deregulated CD8+ T cell cytotoxicity plays a central role in enhancing disease severity in several conditions. However, we have little understanding of the mechanisms by which immunopathology develops as a consequence of cytotoxicity. Using murine models of inflammation induced by the protozoan parasite leishmania, and data obtained from patients with cutaneous leishmaniasis, we uncovered a previously unrecognized role for NLRP3 inflammasome activation and IL-1? release as a detrimental consequence of CD8+ T cell-mediated cytotoxicity, ultimately resulting in chronic inflammation. Critically, pharmacological blockade of NLRP3 or IL-1? significantly ameliorated the CD8+ T cell-driven immunopathology in leishmania-infected mice. Confirming the relevance of these findings to human leishmaniasis, blockade of the NLRP3 inflammasome in skin biopsies from leishmania-infected patients prevented IL-1? release. Thus, these studies link CD8+ T cell cytotoxicity with inflammasome activation and reveal novel avenues of treatment for cutaneous leishmaniasis, as well as other of diseases where CD8+ T cell-mediated cytotoxicity induces pathology. |Animals [MESH] |CD8-Positive T-Lymphocytes/*immunology [MESH] |Cytotoxicity, Immunologic/immunology [MESH] |Flow Cytometry [MESH] |Humans [MESH] |Inflammasomes/*immunology [MESH] |Interleukin-1beta/*biosynthesis/immunology [MESH] |Leishmania braziliensis [MESH] |Leishmaniasis, Cutaneous/*immunology/metabolism/*pathology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/immunology [MESH] |Real-Time Polymerase Chain Reaction [MESH]CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasom(epmc).pdf DeepDyve Pubget Overpricing