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10.1371/journal.pone.0172871 http://scihub22266oqcxt.onion/10.1371/journal.pone.0172871 C5325561!5325561!28235012     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28235012&cmd=llinks): Failed to open stream: HTTP request failed! 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Efficiency of a clinical prediction model for selective rapid testing in children with pharyngitis: A prospective, multicenter study |pdf=|usr=}}{{28235012}} gab.com Text Efficiency of a clinical prediction model for selective rapid testing in children with pharyngitis: A prospective, multicenter study JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28235012 #FOAvip Background: There is controversy whether physicians can rely on signs and symptoms to select children with pharyngitis who should undergo a rapid antigen detection test (RADT) for group A streptococcus (GAS). Our objective was to evaluate the efficiency of signs and symptoms in selectively testing children with pharyngitis. Materials and methods: In this multicenter, prospective, cross-sectional study, French primary care physicians collected clinical data and double throat swabs from 676 consecutive children with pharyngitis; the first swab was used for the RADT and the second was used for a throat culture (reference standard). We developed a logistic regression model combining signs and symptoms with GAS as the outcome. We then derived a model-based selective testing strategy, assuming that children with low and high calculated probability of GAS (<0.12 and >0.85) would be managed without the RADT. Main outcomes and measures were performance of the model (c-index and calibration) and efficiency of the model-based strategy (proportion of participants in whom RADT could be avoided). Results: Throat culture was positive for GAS in 280 participants (41.4%). Out of 17 candidate signs and symptoms, eight were retained in the prediction model. The model had an optimism-corrected c-index of 0.73; calibration of the model was good. With the model-based strategy, RADT could be avoided in 6.6% of participants (95% confidence interval 4.7% to 8.5%), as compared to a RADT-for-all strategy. Conclusions: This study demonstrated that relying on signs and symptoms for selectively testing children with pharyngitis is not efficient. We recommend using a RADT in all children with pharyngitis. Twit Text FOAVip Efficiency of a clinical prediction model for selective rapid testing in children with pharyngitis: A prospective, multicenter study ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28235012 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28235012 #FOAvip English Wikipedia <ref>{{Cite pmid|28235012}}</ref> Efficiency of a clinical prediction model for selective rapid testing in children with pharyngitis: A prospective, multicenter study #MMPMID28235012 Cohen JF; Cohen R; Bidet P; Elbez A; Levy C; Bossuyt PM; Chalumeau M PLoS One 2017[]; 12 (2): ä PMID28235012show ga Background: There is controversy whether physicians can rely on signs and symptoms to select children with pharyngitis who should undergo a rapid antigen detection test (RADT) for group A streptococcus (GAS). Our objective was to evaluate the efficiency of signs and symptoms in selectively testing children with pharyngitis. Materials and methods: In this multicenter, prospective, cross-sectional study, French primary care physicians collected clinical data and double throat swabs from 676 consecutive children with pharyngitis; the first swab was used for the RADT and the second was used for a throat culture (reference standard). We developed a logistic regression model combining signs and symptoms with GAS as the outcome. We then derived a model-based selective testing strategy, assuming that children with low and high calculated probability of GAS (<0.12 and >0.85) would be managed without the RADT. Main outcomes and measures were performance of the model (c-index and calibration) and efficiency of the model-based strategy (proportion of participants in whom RADT could be avoided). Results: Throat culture was positive for GAS in 280 participants (41.4%). Out of 17 candidate signs and symptoms, eight were retained in the prediction model. The model had an optimism-corrected c-index of 0.73; calibration of the model was good. With the model-based strategy, RADT could be avoided in 6.6% of participants (95% confidence interval 4.7% to 8.5%), as compared to a RADT-for-all strategy. Conclusions: This study demonstrated that relying on signs and symptoms for selectively testing children with pharyngitis is not efficient. We recommend using a RADT in all children with pharyngitis. äEfficiency of a clinical prediction model for selective rapid testing (epmc).pdf DeepDyve Pubget Overpricing