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10.18632/oncotarget.11412 http://scihub22266oqcxt.onion/10.18632/oncotarget.11412 C5325459!5325459 !27557497     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27557497 &cmd=llinks): Failed to open stream: HTTP request failed! 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The emerging insights into catalytic or non-catalytic roles of TET proteins in tumors and neural development |pdf=|usr=}}{{27557497 }} gab.com Text The emerging insights into catalytic or non-catalytic roles of TET proteins in tumors and neural development JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27557497 #FOAvip The Ten-eleven translocation (TET) proteins have been recently identified as critical regulators in epigenetic modification, especially in the methylation of cytosine in DNA. TET-mediated DNA oxidation plays prominent roles in a wide variety of physiological and pathological processes, especially in tumor and neural development. TET proteins execute stepwise enzymatic conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). In addition to the more proverbial enzymatic role of TET proteins, TET proteins also possess non-enzymatic activity, through interacting with some epigenetic modifiers. In this review article, we focus on TET proteins dual activities (catalytic or non-catalytic) in tumor and neural development. Hence, the clarification of TET proteins dual activities will contribute to our further understanding of neural development and may open the possibility of new therapeutic avenues to human tumors. Twit Text FOAVip The emerging insights into catalytic or non-catalytic roles of TET proteins in tumors and neural development ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27557497 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27557497 #FOAvip English Wikipedia <ref>{{Cite pmid|27557497 }}</ref> The emerging insights into catalytic or non-catalytic roles of TET proteins in tumors and neural development #MMPMID27557497 Lian H ; Li WB ; Jin WL Oncotarget 2016[Sep]; 7 (39 ): 64512-64525 PMID27557497 show ga The Ten-eleven translocation (TET) proteins have been recently identified as critical regulators in epigenetic modification, especially in the methylation of cytosine in DNA. TET-mediated DNA oxidation plays prominent roles in a wide variety of physiological and pathological processes, especially in tumor and neural development. TET proteins execute stepwise enzymatic conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). In addition to the more proverbial enzymatic role of TET proteins, TET proteins also possess non-enzymatic activity, through interacting with some epigenetic modifiers. In this review article, we focus on TET proteins dual activities (catalytic or non-catalytic) in tumor and neural development. Hence, the clarification of TET proteins dual activities will contribute to our further understanding of neural development and may open the possibility of new therapeutic avenues to human tumors. |*Neurogenesis/genetics [MESH] |5-Methylcytosine/analogs & derivatives/metabolism [MESH] |Animals [MESH] |DNA Methylation [MESH] |Epigenesis, Genetic [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Neoplasm Proteins/chemistry/genetics/*metabolism [MESH] |Neoplasms/*enzymology/genetics/pathology [MESH] |Nerve Tissue Proteins/chemistry/genetics/*metabolism [MESH] |Neurons/*enzymology [MESH] |Protein Conformation [MESH] |Signal Transduction [MESH]The emerging insights into catalytic or non-catalytic roles of TET pro(epmc).pdf DeepDyve Pubget Overpricing