Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27542274
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Oncotarget
2016 ; 7
(39
): 64505-64511
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Suppressive role of myeloid-derived suppressor cells (MDSCs) in the
microenvironment of breast cancer and targeted immunotherapies
#MMPMID27542274
Shou D
; Wen L
; Song Z
; Yin J
; Sun Q
; Gong W
Oncotarget
2016[Sep]; 7
(39
): 64505-64511
PMID27542274
show ga
Myeloid-derived suppressor cells (MDSCs) play a pivotal role in promoting tumor
growth and metastasis and can even decrease the efficacy of immunotherapy. In
breast cancer, MDSCs are recruited mainly by breast cancer cells to form a
tumor-favoring microenvironment to suppress the anti-tumor immune response. In
addition, MDSCs can react directly with breast cancer cells. In this paper, we
describe several ways to recruit MDSCs in breast cancer, including breast cancer
cell-derived cytokines and chemokines. The intracellular pathways in MDSCs during
recruitment are classified as the STAT3-NF-?B-IDO pathway, the STAT3/IRF-8
pathway and the PTEN/Akt pathway. MDSCs act on T cells and NK cells to suppress
the body's immunity, and via IL-6 trans-signaling, promote breast cancer
directly. We further describe MDSC-targeted immune therapies for breast cancer,
which are classified as: preventing the formation of MDSCs, eliminating MDSDCs,
and reducing the products of MDSCs. Furthermore, MDSC-targeted immunotherapy
potentiates the effect of the other immunotherapies. Based on the facts that
MSDCs have significant roles in breast cancer malignant behaviors and can be
suppressed by various strategies, we do believe MDSC-targeted immunotherapy
presents a broad prospect in the future.
|*Molecular Targeted Therapy
[MESH]
|*Tumor Microenvironment
[MESH]
|Animals
[MESH]
|Antineoplastic Agents, Immunological/*therapeutic use
[MESH]