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10.18632/oncotarget.11709 http://scihub22266oqcxt.onion/10.18632/oncotarget.11709 C5325334!5325334 !27588491     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27588491 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (39 ): 62886-62897 Nephropedia Template TP {{tp|p=27588491 |t=2016. Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152 |pdf=|usr=}}{{27588491 }} gab.com Text Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152 JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27588491 #FOAvip Epithelial-mesenchymal transition (EMT) process is considered as a key event in the activation of hepatic stellate cells (HSCs). Hedgehog (Hh) pathway is known to be required for EMT process. Long non-coding RNAs (lncRNAs) have been reported to be involved in a wide range of biological processes. Plasmacytoma variant translocation 1 (PVT1), a novel lncRNA, is often up-regulated in various human cancers. However, the role of PVT1 in liver fibrosis remains undefined. In this study, PVT1 was increased in fibrotic liver tissues and activated HSCs. Depletion of PVT1 attenuated collagen deposits in vivo. In vitro, PVT1 down-regulation inhibited HSC activation including the reduction of HSC proliferation, ?-SMA and type I collagen. Further studies showed that PVT1 knockdown suppressed HSC activation was through inhibiting EMT process and Hh pathway. Patched1 (PTCH1), a negative regulator factor of Hh pathway, was enhanced by PVT1 knockdown. PTCH1 demethylation caused by miR-152 was responsible for the effects of PVT1 knockdown on PTCH1 expression. Notably, miR-152 inhibitor reversed the effects of PVT1 knockdown on HSC activation. Luciferase reporter assays and pull-down assays showed a direct interaction between miR-152 and PVT1. Collectively, we demonstrate that PVT1 epigenetically down-regulates PTCH1 expression via competitively binding miR-152, contributing to EMT process in liver fibrosis. Twit Text FOAVip Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152 ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27588491 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27588491 #FOAvip English Wikipedia <ref>{{Cite pmid|27588491 }}</ref> Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152 #MMPMID27588491 Zheng J ; Yu F ; Dong P ; Wu L ; Zhang Y ; Hu Y ; Zheng L Oncotarget 2016[Sep]; 7 (39 ): 62886-62897 PMID27588491 show ga Epithelial-mesenchymal transition (EMT) process is considered as a key event in the activation of hepatic stellate cells (HSCs). Hedgehog (Hh) pathway is known to be required for EMT process. Long non-coding RNAs (lncRNAs) have been reported to be involved in a wide range of biological processes. Plasmacytoma variant translocation 1 (PVT1), a novel lncRNA, is often up-regulated in various human cancers. However, the role of PVT1 in liver fibrosis remains undefined. In this study, PVT1 was increased in fibrotic liver tissues and activated HSCs. Depletion of PVT1 attenuated collagen deposits in vivo. In vitro, PVT1 down-regulation inhibited HSC activation including the reduction of HSC proliferation, ?-SMA and type I collagen. Further studies showed that PVT1 knockdown suppressed HSC activation was through inhibiting EMT process and Hh pathway. Patched1 (PTCH1), a negative regulator factor of Hh pathway, was enhanced by PVT1 knockdown. PTCH1 demethylation caused by miR-152 was responsible for the effects of PVT1 knockdown on PTCH1 expression. Notably, miR-152 inhibitor reversed the effects of PVT1 knockdown on HSC activation. Luciferase reporter assays and pull-down assays showed a direct interaction between miR-152 and PVT1. Collectively, we demonstrate that PVT1 epigenetically down-regulates PTCH1 expression via competitively binding miR-152, contributing to EMT process in liver fibrosis. |*Epigenesis, Genetic [MESH] |Actins/metabolism [MESH] |Animals [MESH] |Cell Movement [MESH] |Collagen Type I/metabolism [MESH] |Collagen/metabolism [MESH] |CpG Islands [MESH] |DNA Methylation [MESH] |Epithelial-Mesenchymal Transition [MESH] |Fibrosis/pathology [MESH] |Gene Silencing [MESH] |Hepatic Stellate Cells/*metabolism [MESH] |Humans [MESH] |Hydroxyproline/chemistry [MESH] |Liver/metabolism/*pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |MicroRNAs/*metabolism [MESH] |Patched-1 Receptor/*genetics/metabolism [MESH] |RNA Interference [MESH] |RNA, Long Noncoding/*genetics [MESH]Long non-coding RNA PVT1 activates hepatic stellate cells through comp(epmc).pdf DeepDyve Pubget Overpricing