Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28234975
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28234975
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+One
2017 ; 12
(2
): e0172795
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Critical role of intestinal interleukin-4 modulating regulatory T cells for
desensitization, tolerance, and inflammation of food allergy
#MMPMID28234975
Nakajima-Adachi H
; Shibahara K
; Fujimura Y
; Takeyama J
; Hiraide E
; Kikuchi A
; Murakami H
; Hosono A
; Nochi T
; Wakatsuki Y
; Shimojo N
; Kaminogawa S
; Sato R
; Kiyono H
; Hachimura S
PLoS One
2017[]; 12
(2
): e0172795
PMID28234975
show ga
BACKGROUND AND OBJECTIVE: The mechanism inducing either inflammation or tolerance
to orally administered food allergens remains unclear. To investigate this we
analyzed mouse models of food allergy (OVA23-3) and tolerance (DO11.10 [D10]),
both of which express ovalbumin (OVA)-specific T-cell receptors. METHODS:
OVA23-3, recombination activating gene (RAG)-2-deficient OVA23-3 (R23-3), D10,
and RAG-2-deficient D10 (RD10) mice consumed a diet containing egg white (EW
diet) for 2-28 days. Interleukin (IL)-4 production by CD4+ T cells was measured
as a causative factor of enteropathy, and anti-IL-4 antibody was used to reveal
the role of Foxp3+ OVA-specific Tregs (aiTreg) in this process. RESULTS: Unlike
OVA23-3 and R23-3 mice, D10 and RD10 mice did not develop enteropathy and weight
loss on the EW diet. On days 7-10, in EW-fed D10 and RD10 mice, splenic CD4+ T
cells produced significantly more IL-4 than did those in the mesenteric lymph
nodes (MLNs); this is in contrast to the excessive IL-4 response in the MLNs of
EW-fed OVA23-3 and R23-3 mice. EW-fed R23-3 mice had few aiTregs, whereas EW-fed
RD10 mice had them in both tissues. Intravenous injections of anti-IL-4 antibody
recovered the percentage of aiTregs in the MLNs of R23-3 mice. On day 28, in
EW-fed OVA23-3 and R23-3 mice, expression of Foxp3 on CD4+ T cells corresponded
with recovery from inflammation, but recurrence of weight loss was observed on
restarting the EW diet after receiving the control-diet for 1 month. No
recurrence developed in D10 mice. CONCLUSIONS: Excessive IL-4 levels in the MLNs
directly inhibited the induction of aiTregs and caused enteropathy. The aiTregs
generated in the attenuation of T cell-dependent food allergic enteropathy may
function differently than aiTregs induced in a tolerance model. Comparing the two
models enables to investigate their aiTreg functions and to clarify differences
between inflammation with subsequent desensitization versus tolerance.
free
free
free
