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10.1016/j.ddtec.2016.09.001 http://scihub22266oqcxt.onion/10.1016/j.ddtec.2016.09.001 C5325140!5325140!27769355     free     free     free       Drug+Discov+Today+Technol 2016 ; 19 (ä): 3-15 Nephropedia Template TP {{tp|p=27769355|t=2016. Structural Features and Inhibitors of Bromodomains |pdf=|usr=}}{{27769355}} gab.com Text Structural Features and Inhibitors of Bromodomains JO: Drug Discov Today Technol http://www.kidney.de/pget.php?&tw=1&pmid=27769355 #FOAvip Bromodomains are conserved structural modules responsible for recognizing acetylated-lysine residues on histone tails and other transcription-associated proteins, such as transcription factors and co-factors. Owing to their important functions in the regulation of ordered gene transcription in chromatin, bromodomains of the BET family proteins have recently been shown as druggable targets for a wide array of human diseases, including cancer and inflammation. Here we review the structural and functional features of the bromodomains and their small-molecule inhibitors. Additional new insights provided herein highlight the landscape of the ligand binding sites in the bromodomains that will hopefully facilitate further development of new inhibitors with optimal affinity and selectivity. Twit Text FOAVip Structural Features and Inhibitors of Bromodomains ????Drug Discov Today Technol http://www.kidney.de/pget.php?&tw=1&pmid=27769355 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27769355 #FOAvip English Wikipedia <ref>{{Cite pmid|27769355}}</ref> Structural Features and Inhibitors of Bromodomains #MMPMID27769355 Meslamani J; Smith SG; Sanchez R; Zhou MM Drug Discov Today Technol 2016[Mar]; 19 (ä): 3-15 PMID27769355show ga Bromodomains are conserved structural modules responsible for recognizing acetylated-lysine residues on histone tails and other transcription-associated proteins, such as transcription factors and co-factors. Owing to their important functions in the regulation of ordered gene transcription in chromatin, bromodomains of the BET family proteins have recently been shown as druggable targets for a wide array of human diseases, including cancer and inflammation. Here we review the structural and functional features of the bromodomains and their small-molecule inhibitors. Additional new insights provided herein highlight the landscape of the ligand binding sites in the bromodomains that will hopefully facilitate further development of new inhibitors with optimal affinity and selectivity. äStructural Features and Inhibitors of Bromodomains (epmc).pdf DeepDyve Pubget Overpricing