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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Clin+Periodontol
2016 ; 43
(2
): 104-13
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Association between periodontitis and mortality in stages 3-5 chronic kidney
disease: NHANES III and linked mortality study
#MMPMID26717883
Sharma P
; Dietrich T
; Ferro CJ
; Cockwell P
; Chapple IL
J Clin Periodontol
2016[Feb]; 43
(2
): 104-13
PMID26717883
show ga
INTRODUCTION: Periodontitis may add to the systemic inflammatory burden in
individuals with chronic kidney disease (CKD), thereby contributing to an
increased mortality rate. This study aimed to determine the association between
periodontitis and mortality rate (all-cause and cardiovascular disease-related)
in individuals with stage 3-5 CKD, hitherto referred to as "CKD". METHODS:
Survival analysis was carried out using the Third National Health and Nutrition
Examination Survey (NHANES III) and linked mortality data. Cox proportional
hazards regression was employed to assess the association between periodontitis
and mortality, in individuals with CKD. This association was compared with the
association between mortality and traditional risk factors in CKD mortality
(diabetes, hypertension and smoking). RESULTS: Of the 13,784 participants
eligible for analysis in NHANES III, 861 (6%) had CKD. The median follow-up for
this cohort was 14.3 years. Adjusting for confounders, the 10-year all-cause
mortality rate for individuals with CKD increased from 32% (95% CI: 29-35%) to
41% (36-47%) with the addition of periodontitis. For diabetes, the 10-year
all-cause mortality rate increased to 43% (38-49%). CONCLUSION: There is a
strong, association between periodontitis and increased mortality in individuals
with CKD. Sources of chronic systemic inflammation (including periodontitis) may
be important contributors to mortality in patients with CKD.