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Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 BMC+Med 2017 ; 15 (ä): ä Nephropedia Template TP
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Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects #MMPMID28231783
Di Donato I; Bianchi S; De Stefano N; Dichgans M; Dotti MT; Duering M; Jouvent E; Korczyn AD; Lesnik-Oberstein SAJ; Malandrini A; Markus HS; Pantoni L; Penco S; Rufa A; Sinanovi? O; Stojanov D; Federico A
BMC Med 2017[]; 15 (ä): ä PMID28231783show ga
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common and best known monogenic small vessel disease. Here, we review the clinical, neuroimaging, neuropathological, genetic, and therapeutic aspects based on the most relevant articles published between 1994 and 2016 and on the personal experience of the authors, all directly involved in CADASIL research and care. We conclude with some suggestions that may help in the clinical practice and management of these patients.