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10.1038/srep43434 http://scihub22266oqcxt.onion/10.1038/srep43434 C5324061!5324061 !28233834     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28233834 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): 43434 Nephropedia Template TP {{tp|p=28233834 |t=2017. Untangling the role of one-carbon metabolism in colorectal cancer risk: a comprehensive Bayesian network analysis |pdf=|usr=}}{{28233834 }} gab.com Text Untangling the role of one-carbon metabolism in colorectal cancer risk: a comprehensive Bayesian network analysis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28233834 #FOAvip The role of one-carbon metabolism (1CM), particularly folate, in colorectal cancer (CRC) development has been extensively studied, but with inconclusive results. Given the complexity of 1CM, the conventional approach, investigating components individually, may be insufficient. We used a machine learning-based Bayesian network approach to study, simultaneously, 14 circulating one-carbon metabolites, 17 related single nucleotide polymorphisms (SNPs), and several environmental factors in relation to CRC risk in 613 cases and 1190 controls from the prospective Northern Sweden Health and Disease Study. The estimated networks corresponded largely to known biochemical relationships. Plasma concentrations of folate (direct), vitamin B6 (pyridoxal 5-phosphate) (inverse), and vitamin B2 (riboflavin) (inverse) had the strongest independent associations with CRC risk. Our study demonstrates the importance of incorporating B-vitamins in future studies of 1CM and CRC development, and the usefulness of Bayesian network learning for investigating complex biological systems in relation to disease. Twit Text FOAVip Untangling the role of one-carbon metabolism in colorectal cancer risk: a comprehensive Bayesian network analysis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28233834 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28233834 #FOAvip English Wikipedia <ref>{{Cite pmid|28233834 }}</ref> Untangling the role of one-carbon metabolism in colorectal cancer risk: a comprehensive Bayesian network analysis #MMPMID28233834 Myte R ; Gylling B ; Häggström J ; Schneede J ; Magne Ueland P ; Hallmans G ; Johansson I ; Palmqvist R ; Van Guelpen B Sci Rep 2017[Feb]; 7 (ä): 43434 PMID28233834 show ga The role of one-carbon metabolism (1CM), particularly folate, in colorectal cancer (CRC) development has been extensively studied, but with inconclusive results. Given the complexity of 1CM, the conventional approach, investigating components individually, may be insufficient. We used a machine learning-based Bayesian network approach to study, simultaneously, 14 circulating one-carbon metabolites, 17 related single nucleotide polymorphisms (SNPs), and several environmental factors in relation to CRC risk in 613 cases and 1190 controls from the prospective Northern Sweden Health and Disease Study. The estimated networks corresponded largely to known biochemical relationships. Plasma concentrations of folate (direct), vitamin B6 (pyridoxal 5-phosphate) (inverse), and vitamin B2 (riboflavin) (inverse) had the strongest independent associations with CRC risk. Our study demonstrates the importance of incorporating B-vitamins in future studies of 1CM and CRC development, and the usefulness of Bayesian network learning for investigating complex biological systems in relation to disease. |Adult [MESH] |Aged [MESH] |Bayes Theorem [MESH] |Biomarkers, Tumor/*blood/genetics [MESH] |Carbon/metabolism [MESH] |Case-Control Studies [MESH] |Colorectal Neoplasms/blood/*diagnosis/genetics [MESH] |Female [MESH] |Folic Acid/*blood [MESH] |Humans [MESH] |Machine Learning [MESH] |Male [MESH] |Metabolome [MESH] |Middle Aged [MESH] |Neoplasm Proteins/*blood/genetics [MESH] |Polymorphism, Single Nucleotide [MESH] |Riboflavin/*blood [MESH] |Risk Factors [MESH]Untangling the role of one-carbon metabolism in colorectal cancer risk(epmc).pdf DeepDyve Pubget Overpricing