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2017 ; 7
(1
): 81-87
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Contrast-induced acute kidney injury in kidney transplant recipients: A
systematic review and meta-analysis
#MMPMID28280699
Cheungpasitporn W
; Thongprayoon C
; Mao MA
; Mao SA
; D'Costa MR
; Kittanamongkolchai W
; Kashani KB
World J Transplant
2017[Feb]; 7
(1
): 81-87
PMID28280699
show ga
AIM: To evaluate the incidence of contrast-induced acute kidney injury (CIAKI) in
kidney transplant recipients. METHODS: A literature search was performed using
MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews from the
inception of the databases through July 2016. Studies assessing the incidence of
CIAKI in kidney transplant recipients were included. We applied a random-effects
model to estimate the incidence of CIAKI. RESULTS: Six studies of 431 kidney
transplant recipients were included in the analyses to assess the incidence of
CIAKI in kidney transplant recipients. The estimated incidence of CIAKI and
CIAKI-requiring dialysis were 9.6% (95%CI: 4.5%-16.3%) and 0.4% (95%CI:
0.0%-1.2%), respectively. A sensitivity analysis limited only to the studies that
used low-osmolar or iso-osmolar contrast showed the estimated incidence of CIAKI
was 8.0% (95%CI: 3.5%-14.2%). The estimated incidences of CIAKI in recipients who
received contrast media with cardiac catheterization, other types of angiogram,
and CT scan were 16.1% (95%CI: 6.6%-28.4%), 10.1% (95%CI: 4.2%-18.0%), and 6.1%
(95%CI: 1.8%-12.4%), respectively. No graft losses were reported within 30 d
post-contrast media administration. However, data on the effects of CIAKI on
long-term graft function were limited. CONCLUSION: The estimated incidence of
CIAKI in kidney transplant recipients is 9.6%. The risk stratification should be
considered based on allograft function, indication, and type of procedure.