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10.1111/jcmm.12986 http://scihub22266oqcxt.onion/10.1111/jcmm.12986 C5323876!5323876!27677429     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2017 ; 21 (3): 422-31 Nephropedia Template TP {{tp|p=27677429|t=2017. Genistein suppresses leptin?induced proliferation and migration of vascular smooth muscle cells and neointima formation |pdf=|usr=}}{{27677429}} gab.com Text Genistein suppresses leptin induced proliferation and migration of vascular smooth muscle cells and neointima formation JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27677429 #FOAvip Obesity is a strong risk factor for the development of cardiovascular diseases and is associated with a marked increase in circulating leptin concentration. Leptin is a peptide hormone mainly produced by adipose tissue and is regulated by energy level, hormones and various inflammatory mediators. Genistein is an isoflavone that exhibits diverse health?promoting effects. Here, we investigated whether genistein suppressed the atherogenic effect induced by leptin. The A10 cells were treated with leptin and/or genistein, and then the cell proliferation and migration were analysed. The reactive oxygen species (ROS) and proteins levels were also measured, such as p44/42MAPK, cell cycle?related protein (cyclin D1 and p21) and matrix metalloproteinase?2 (MMP?2). Immunohistochemistry and morphometric analysis were used for the neointima formation in a rat carotid artery injury model. Genistein (5 ?M) significantly inhibited both the proliferation and migration of leptin (10 ng/ml)?stimulated A10 cells. In accordance with these finding, genistein decreased the leptin?stimulated ROS production and phosphorylation of the p44/42MAPK signal transduction pathway. Meanwhile, genistein reversed the leptin?induced expression of cyclin D1, and cyclin?dependent kinase inhibitor, p21. Genistein attenuated leptin?induced A10 cell migration by inhibiting MMP?2 activity. Furthermore, the leptin (0.25 mg/kg)?augmented neointima formation in a rat carotid artery injury model was attenuated in the genistein (5 mg/kg body weight)?treated group when compared with the balloon injury plus leptin group. Genistein was capable of suppressing the atherogenic effects of leptin in vitro and in vivo, and may be a promising candidate drug in the clinical setting. Twit Text FOAVip Genistein suppresses leptin induced proliferation and migration of vascular smooth muscle cells and neointima formation ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27677429 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27677429 #FOAvip English Wikipedia <ref>{{Cite pmid|27677429}}</ref> Genistein suppresses leptin?induced proliferation and migration of vascular smooth muscle cells and neointima formation #MMPMID27677429 Tsai Y; Leu S; Peng Y; Lee Y; Hsu C; Chou S; Yen M; Cheng P J Cell Mol Med 2017[Mar]; 21 (3): 422-31 PMID27677429show ga Obesity is a strong risk factor for the development of cardiovascular diseases and is associated with a marked increase in circulating leptin concentration. Leptin is a peptide hormone mainly produced by adipose tissue and is regulated by energy level, hormones and various inflammatory mediators. Genistein is an isoflavone that exhibits diverse health?promoting effects. Here, we investigated whether genistein suppressed the atherogenic effect induced by leptin. The A10 cells were treated with leptin and/or genistein, and then the cell proliferation and migration were analysed. The reactive oxygen species (ROS) and proteins levels were also measured, such as p44/42MAPK, cell cycle?related protein (cyclin D1 and p21) and matrix metalloproteinase?2 (MMP?2). Immunohistochemistry and morphometric analysis were used for the neointima formation in a rat carotid artery injury model. Genistein (5 ?M) significantly inhibited both the proliferation and migration of leptin (10 ng/ml)?stimulated A10 cells. In accordance with these finding, genistein decreased the leptin?stimulated ROS production and phosphorylation of the p44/42MAPK signal transduction pathway. Meanwhile, genistein reversed the leptin?induced expression of cyclin D1, and cyclin?dependent kinase inhibitor, p21. Genistein attenuated leptin?induced A10 cell migration by inhibiting MMP?2 activity. Furthermore, the leptin (0.25 mg/kg)?augmented neointima formation in a rat carotid artery injury model was attenuated in the genistein (5 mg/kg body weight)?treated group when compared with the balloon injury plus leptin group. Genistein was capable of suppressing the atherogenic effects of leptin in vitro and in vivo, and may be a promising candidate drug in the clinical setting. äGenistein suppresses leptin?induced proliferation and migration of vas(epmc).pdf DeepDyve Pubget Overpricing