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10.1111/jcmm.12990 http://scihub22266oqcxt.onion/10.1111/jcmm.12990 C5323864!5323864!27680680     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27680680&cmd=llinks): Failed to open stream: HTTP request failed! 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MicroRNA?21 protects against cardiac hypoxia/reoxygenation injury by inhibiting excessive autophagy in H9c2 cells via the Akt/mTOR pathway |pdf=|usr=}}{{27680680}} gab.com Text MicroRNA 21 protects against cardiac hypoxia/reoxygenation injury by inhibiting excessive autophagy in H9c2 cells via the Akt/mTOR pathway JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27680680 #FOAvip MicroRNAs and autophagy play critical roles in cardiac hypoxia/reoxygenation (H/R)?induced injury. Here, we investigated the function of miR?21 in regulating autophagy and identified the potential molecular mechanisms involved. To determine the role of miR?21 in regulating autophagy, H9c2 cells were divided into the following six groups: control group, H/R group, (miR?21+ H/R) group, (miR?21?negative control + H/R) group, (BEZ235+ H/R) group and (miR?21+ BEZ235+ H/R) group. The cells underwent hypoxia for 1 hr and reoxygenation for 3 hrs. Cell count kit?8 was used to evaluate cell function and apoptosis was analysed by Western blotting. Western blotting and transmission electron microscopy were used to investigate autophagy. We found that miR?21 expression was down?regulated, and autophagy was remarkably increased in H9c2 cells during H/R injury. Overexpression of miR?21 with a miR?21 precursor significantly inhibited autophagic activity and decreased apoptosis, accompanied by the activation of the AKT/mTOR pathway. In addition, treatment with BEZ235, a novel dual Akt/mTOR inhibitor, resulted in a significant increase in autophagy and apoptosis. However, we found that miR?21?mediated inhibition of apoptosis and autophagy was partly independent of Akt/mTOR activation, as demonstrated in cells treated with both miR?21 and BEZ235. We showed that miR?21 could inhibit H/R?induced autophagy and apoptosis, which may be at least partially mediated by the Akt/mTOR signalling pathway. Twit Text FOAVip MicroRNA 21 protects against cardiac hypoxia/reoxygenation injury by inhibiting excessive autophagy in H9c2 cells via the Akt/mTOR pathway ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27680680 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27680680 #FOAvip English Wikipedia <ref>{{Cite pmid|27680680}}</ref> MicroRNA?21 protects against cardiac hypoxia/reoxygenation injury by inhibiting excessive autophagy in H9c2 cells via the Akt/mTOR pathway #MMPMID27680680 Huang Z; Wu S; Kong F; Cai X; Ye B; Shan P; Huang W J Cell Mol Med 2017[Mar]; 21 (3): 467-74 PMID27680680show ga MicroRNAs and autophagy play critical roles in cardiac hypoxia/reoxygenation (H/R)?induced injury. Here, we investigated the function of miR?21 in regulating autophagy and identified the potential molecular mechanisms involved. To determine the role of miR?21 in regulating autophagy, H9c2 cells were divided into the following six groups: control group, H/R group, (miR?21+ H/R) group, (miR?21?negative control + H/R) group, (BEZ235+ H/R) group and (miR?21+ BEZ235+ H/R) group. The cells underwent hypoxia for 1 hr and reoxygenation for 3 hrs. Cell count kit?8 was used to evaluate cell function and apoptosis was analysed by Western blotting. Western blotting and transmission electron microscopy were used to investigate autophagy. We found that miR?21 expression was down?regulated, and autophagy was remarkably increased in H9c2 cells during H/R injury. Overexpression of miR?21 with a miR?21 precursor significantly inhibited autophagic activity and decreased apoptosis, accompanied by the activation of the AKT/mTOR pathway. In addition, treatment with BEZ235, a novel dual Akt/mTOR inhibitor, resulted in a significant increase in autophagy and apoptosis. However, we found that miR?21?mediated inhibition of apoptosis and autophagy was partly independent of Akt/mTOR activation, as demonstrated in cells treated with both miR?21 and BEZ235. We showed that miR?21 could inhibit H/R?induced autophagy and apoptosis, which may be at least partially mediated by the Akt/mTOR signalling pathway. äMicroRNA?21 protects against cardiac hypoxia/reoxygenation injury by i(epmc).pdf DeepDyve Pubget Overpricing