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10.1002/advs.201600228 http://scihub22266oqcxt.onion/10.1002/advs.201600228 C5323819!5323819!28251047     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Sci+(Weinh) 2017 ; 4 (2): ä Nephropedia Template TP {{tp|p=28251047|t=2017. SiRNA Crosslinked Nanoparticles for the Treatment of Inflammation?induced Liver Injury |pdf=|usr=}}{{28251047}} gab.com Text SiRNA Crosslinked Nanoparticles for the Treatment of Inflammation induced Liver Injury JO: Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=28251047 #FOAvip RNA interference mediated by small interfering RNA (siRNA) provides a powerful tool for gene regulation, and has a broad potential as a promising therapeutic strategy. However, therapeutics based on siRNA have had limited clinical success due to their undesirable pharmacokinetic properties. This study presents pH?sensitive nanoparticles?based siRNA delivery systems (PNSDS), which are positive?charge?free nanocarriers, composed of siRNA chemically crosslinked with multi?armed poly(ethylene glycol) carriers via acid?labile acetal linkers. The unique siRNA crosslinked structure of PNSDS allows it to have minimal cytotoxicity, high siRNA loading efficiency, and a stimulus?responsive property that enables the selective intracellular release of siRNA in response to pH conditions. This study demonstrates that PNSDS can deliver tumor necrosis factor alpha (TNF??) siRNA into macrophages and induce the efficient down regulation of the targeted gene in complete cell culture media. Moreover, PNSDS with mannose targeting moieties can selectively accumulate in mice liver, induce specific inhibition of macrophage TNF?? expression in vivo, and consequently protect mice from inflammation?induced liver damages. Therefore, this novel siRNA delivering platform would greatly improve the therapeutic potential of RNAi based therapies. Twit Text FOAVip SiRNA Crosslinked Nanoparticles for the Treatment of Inflammation induced Liver Injury ????Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=28251047 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28251047 #FOAvip English Wikipedia <ref>{{Cite pmid|28251047}}</ref> SiRNA Crosslinked Nanoparticles for the Treatment of Inflammation?induced Liver Injury #MMPMID28251047 Tang Y; Zeng Z; He X; Wang T; Ning X; Feng X Adv Sci (Weinh) 2017[Feb]; 4 (2): ä PMID28251047show ga RNA interference mediated by small interfering RNA (siRNA) provides a powerful tool for gene regulation, and has a broad potential as a promising therapeutic strategy. However, therapeutics based on siRNA have had limited clinical success due to their undesirable pharmacokinetic properties. This study presents pH?sensitive nanoparticles?based siRNA delivery systems (PNSDS), which are positive?charge?free nanocarriers, composed of siRNA chemically crosslinked with multi?armed poly(ethylene glycol) carriers via acid?labile acetal linkers. The unique siRNA crosslinked structure of PNSDS allows it to have minimal cytotoxicity, high siRNA loading efficiency, and a stimulus?responsive property that enables the selective intracellular release of siRNA in response to pH conditions. This study demonstrates that PNSDS can deliver tumor necrosis factor alpha (TNF??) siRNA into macrophages and induce the efficient down regulation of the targeted gene in complete cell culture media. Moreover, PNSDS with mannose targeting moieties can selectively accumulate in mice liver, induce specific inhibition of macrophage TNF?? expression in vivo, and consequently protect mice from inflammation?induced liver damages. Therefore, this novel siRNA delivering platform would greatly improve the therapeutic potential of RNAi based therapies. äSiRNA Crosslinked Nanoparticles for the Treatment of Inflammation?indu(epmc).pdf DeepDyve Pubget Overpricing