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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 World+J+Gastroenterol
2017 ; 23
(7
): 1319-1324
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Clinical and immunologic effects of faecal microbiota transplantation in a
patient with collagenous colitis
#MMPMID28275312
Günaltay S
; Rademacher L
; Hultgren Hörnquist E
; Bohr J
World J Gastroenterol
2017[Feb]; 23
(7
): 1319-1324
PMID28275312
show ga
One to six percent of patients with microscopic colitis are refractory to medical
treatment. The effect of faecal microbiota transplantation (FMT) in active
collagenous colitis (CC) has, to the best of our knowledge, never been reported
before. Here, we report the effect of repeated FMT in a patient with CC. The
patient presented with severe symptoms including profuse diarrhea and profound
weight loss. Although she responded to budesonide in the beginning, she became
gradually refractory to medical treatment, and was therefore treated with FMT.
The patient remained in remission for 11 mo after the third faecal
transplantation. The immunomodulatory effect of the therapy was evaluated using
flow cytometry, which showed alterations in the profile of intraepithelial and
lamina propria lymphocyte subsets after the second transplantation. Our
observations indicate that FMT can have an effect in CC, which support the
hypothesis that luminal factors, influencing the intestinal microbiota, are
involved in the pathogenesis of CC.