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10.18632/oncotarget.11357 http://scihub22266oqcxt.onion/10.18632/oncotarget.11357 C5323231!5323231 !27542261     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27542261 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (40 ): 66255-66266 Nephropedia Template TP {{tp|p=27542261 |t=2016. Targeting binding partners of the CBF?-SMMHC fusion protein for the treatment of inversion 16 acute myeloid leukemia |pdf=|usr=}}{{27542261 }} gab.com Text Targeting binding partners of the CBF -SMMHC fusion protein for the treatment of inversion 16 acute myeloid leukemia JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27542261 #FOAvip Inversion of chromosome 16 (inv(16)) generates the CBF?-SMMHC fusion protein and is found in nearly all patients with acute myeloid leukemia subtype M4 with Eosinophilia (M4Eo). Expression of CBF?-SMMHC is causative for leukemia development, but the molecular mechanisms underlying its activity are unclear. Recently, there have been important advances in defining the role of CBF?-SMMHC and its binding partners, the transcription factor RUNX1 and the histone deacetylase HDAC8. Importantly, initial trials demonstrate that small molecules targeting these binding partners are effective against CBF?-SMMHC induced leukemia. This review will discuss recent advances in defining the mechanism of CBF?-SMMHC activity, as well as efforts to develop new therapies for inv(16) AML. Twit Text FOAVip Targeting binding partners of the CBF -SMMHC fusion protein for the treatment of inversion 16 acute myeloid leukemia ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27542261 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27542261 #FOAvip English Wikipedia <ref>{{Cite pmid|27542261 }}</ref> Targeting binding partners of the CBF?-SMMHC fusion protein for the treatment of inversion 16 acute myeloid leukemia #MMPMID27542261 Richter L ; Wang Y ; Hyde RK Oncotarget 2016[Oct]; 7 (40 ): 66255-66266 PMID27542261 show ga Inversion of chromosome 16 (inv(16)) generates the CBF?-SMMHC fusion protein and is found in nearly all patients with acute myeloid leukemia subtype M4 with Eosinophilia (M4Eo). Expression of CBF?-SMMHC is causative for leukemia development, but the molecular mechanisms underlying its activity are unclear. Recently, there have been important advances in defining the role of CBF?-SMMHC and its binding partners, the transcription factor RUNX1 and the histone deacetylase HDAC8. Importantly, initial trials demonstrate that small molecules targeting these binding partners are effective against CBF?-SMMHC induced leukemia. This review will discuss recent advances in defining the mechanism of CBF?-SMMHC activity, as well as efforts to develop new therapies for inv(16) AML. |*Chromosome Inversion [MESH] |*Chromosomes, Human, Pair 16 [MESH] |Antineoplastic Agents/pharmacology [MESH] |Core Binding Factor Alpha 2 Subunit/*antagonists & inhibitors/metabolism [MESH] |Histone Deacetylases/metabolism [MESH] |Humans [MESH] |Leukemia, Myeloid, Acute/drug therapy/*genetics/metabolism [MESH] |Oncogene Proteins, Fusion/*genetics/metabolism [MESH] |Protein Binding [MESH] |Protein Interaction Maps/*drug effects [MESH]Targeting binding partners of the CBF?-SMMHC fusion protein for the tr(epmc).pdf DeepDyve Pubget Overpricing