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10.18632/oncotarget.11807 http://scihub22266oqcxt.onion/10.18632/oncotarget.11807 C5323217!5323217!27602774     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (40): 66087-99 Nephropedia Template TP {{tp|p=27602774|t=2016. Circadian clock components ROR? and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells |pdf=|usr=}}{{27602774}} gab.com Text Circadian clock components ROR and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27602774 #FOAvip The anticancer small molecule MLN4924, a Nedd8-activating enzyme (NAE) inhibitor, triggers cell-cycle arrest, apoptosis, and senescence in cancer cells. In this study, we demonstrate that MLN4924 suppresses osteosarcoma cell proliferation by inducing G2/M cell cycle arrest and apoptosis. Our results indicate that MLN4924 stabilizes the retinoid orphan nuclear receptor alpha (ROR?) by decreasing its ubiquitination. RNA interference of ROR? attenuates the anti-proliferative effect of MLN4924 in U2OS osteosarcoma cells. MLN4924 up-regulates the expression of p21 and Bmal1, two transcriptional targets of ROR?. However, p21 plays a minimal role in the anti-proliferative effect of MLN4924 in U2OS osteosarcoma cells. In contrast, Bmal1 suppression by siRNA attenuates the anti-proliferative effect of MLN4924 in U2OS osteosarcoma cells, indicating that the MLN4924-mediated cell growth inhibition is mediated by Bmal1. These results show MLN4924 to be a promising therapeutic agent for the treatment of osteosarcoma and suggest that MLN4924-induced tumor growth inhibition is mediated by the circadian clock components ROR? and Bmal1. Twit Text FOAVip Circadian clock components ROR and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27602774 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27602774 #FOAvip English Wikipedia <ref>{{Cite pmid|27602774}}</ref> Circadian clock components ROR? and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells #MMPMID27602774 Zhang S; Zhang J; Deng Z; Liu H; Mao W; Jiang F; Xia Z; Li JD Oncotarget 2016[Oct]; 7 (40): 66087-99 PMID27602774show ga The anticancer small molecule MLN4924, a Nedd8-activating enzyme (NAE) inhibitor, triggers cell-cycle arrest, apoptosis, and senescence in cancer cells. In this study, we demonstrate that MLN4924 suppresses osteosarcoma cell proliferation by inducing G2/M cell cycle arrest and apoptosis. Our results indicate that MLN4924 stabilizes the retinoid orphan nuclear receptor alpha (ROR?) by decreasing its ubiquitination. RNA interference of ROR? attenuates the anti-proliferative effect of MLN4924 in U2OS osteosarcoma cells. MLN4924 up-regulates the expression of p21 and Bmal1, two transcriptional targets of ROR?. However, p21 plays a minimal role in the anti-proliferative effect of MLN4924 in U2OS osteosarcoma cells. In contrast, Bmal1 suppression by siRNA attenuates the anti-proliferative effect of MLN4924 in U2OS osteosarcoma cells, indicating that the MLN4924-mediated cell growth inhibition is mediated by Bmal1. These results show MLN4924 to be a promising therapeutic agent for the treatment of osteosarcoma and suggest that MLN4924-induced tumor growth inhibition is mediated by the circadian clock components ROR? and Bmal1. äCircadian clock components ROR? and Bmal1 mediate the anti-proliferati(epmc).pdf DeepDyve Pubget Overpricing