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10.18632/oncotarget.11807 http://scihub22266oqcxt.onion/10.18632/oncotarget.11807 C5323217!5323217 !27602774     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27602774 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (40 ): 66087-66099 Nephropedia Template TP {{tp|p=27602774 |t=2016. Circadian clock components ROR? and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells |pdf=|usr=}}{{27602774 }} gab.com Text Circadian clock components ROR and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27602774 #FOAvip The anticancer small molecule MLN4924, a Nedd8-activating enzyme (NAE) inhibitor, triggers cell-cycle arrest, apoptosis, and senescence in cancer cells. In this study, we demonstrate that MLN4924 suppresses osteosarcoma cell proliferation by inducing G2/M cell cycle arrest and apoptosis. Our results indicate that MLN4924 stabilizes the retinoid orphan nuclear receptor alpha (ROR?) by decreasing its ubiquitination. RNA interference of ROR? attenuates the anti-proliferative effect of MLN4924 in U2OS osteosarcoma cells. MLN4924 up-regulates the expression of p21 and Bmal1, two transcriptional targets of ROR?. However, p21 plays a minimal role in the anti-proliferative effect of MLN4924 in U2OS osteosarcoma cells. In contrast, Bmal1 suppression by siRNA attenuates the anti-proliferative effect of MLN4924 in U2OS osteosarcoma cells, indicating that the MLN4924-mediated cell growth inhibition is mediated by Bmal1. These results show MLN4924 to be a promising therapeutic agent for the treatment of osteosarcoma and suggest that MLN4924-induced tumor growth inhibition is mediated by the circadian clock components ROR? and Bmal1. Twit Text FOAVip Circadian clock components ROR and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27602774 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27602774 #FOAvip English Wikipedia <ref>{{Cite pmid|27602774 }}</ref> Circadian clock components ROR? and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells #MMPMID27602774 Zhang S ; Zhang J ; Deng Z ; Liu H ; Mao W ; Jiang F ; Xia Z ; Li JD Oncotarget 2016[Oct]; 7 (40 ): 66087-66099 PMID27602774 show ga The anticancer small molecule MLN4924, a Nedd8-activating enzyme (NAE) inhibitor, triggers cell-cycle arrest, apoptosis, and senescence in cancer cells. In this study, we demonstrate that MLN4924 suppresses osteosarcoma cell proliferation by inducing G2/M cell cycle arrest and apoptosis. Our results indicate that MLN4924 stabilizes the retinoid orphan nuclear receptor alpha (ROR?) by decreasing its ubiquitination. RNA interference of ROR? attenuates the anti-proliferative effect of MLN4924 in U2OS osteosarcoma cells. MLN4924 up-regulates the expression of p21 and Bmal1, two transcriptional targets of ROR?. However, p21 plays a minimal role in the anti-proliferative effect of MLN4924 in U2OS osteosarcoma cells. In contrast, Bmal1 suppression by siRNA attenuates the anti-proliferative effect of MLN4924 in U2OS osteosarcoma cells, indicating that the MLN4924-mediated cell growth inhibition is mediated by Bmal1. These results show MLN4924 to be a promising therapeutic agent for the treatment of osteosarcoma and suggest that MLN4924-induced tumor growth inhibition is mediated by the circadian clock components ROR? and Bmal1. |*Circadian Clocks [MESH] |ARNTL Transcription Factors/*metabolism [MESH] |Animals [MESH] |Apoptosis/drug effects [MESH] |Biomarkers, Tumor/metabolism [MESH] |Bone Neoplasms/*drug therapy/metabolism/pathology [MESH] |Cell Proliferation/*drug effects [MESH] |Cyclopentanes/*pharmacology [MESH] |Enzyme Inhibitors/pharmacology [MESH] |Humans [MESH] |Mice [MESH] |Mice, Nude [MESH] |Nuclear Receptor Subfamily 1, Group F, Member 1/*metabolism [MESH] |Osteosarcoma/*drug therapy/metabolism/pathology [MESH] |Pyrimidines/*pharmacology [MESH] |Tumor Cells, Cultured [MESH]Circadian clock components ROR? and Bmal1 mediate the anti-proliferati(epmc).pdf DeepDyve Pubget Overpricing