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10.18632/oncotarget.11395 http://scihub22266oqcxt.onion/10.18632/oncotarget.11395 C5323164!5323164!27557492     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (40): 65403-17 Nephropedia Template TP {{tp|p=27557492|t=2016. Foxp3 enhances HIF-1? target gene expression in human bladder cancer through decreasing its ubiquitin-proteasomal degradation |pdf=|usr=}}{{27557492}} gab.com Text Foxp3 enhances HIF-1 target gene expression in human bladder cancer through decreasing its ubiquitin-proteasomal degradation JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27557492 #FOAvip Hypoxia-inducible factor-1? (HIF-1?) can control a transcriptional factor forkhead box P3 (Foxp3) protein expression in T lymphocyte differentiation through proteasome-mediated degradation. In this study, we unveil a reverse regulatory mechanism contributing to bladder cancer progression; Foxp3 expression attenuates HIF-1? degradation. We first demonstrated that Foxp3 expression positively correlates with the metastatic potential in T24 cells and can increase the expression of HIF-1?-target genes, such as vascular endothelial growth factor (VEGF) and glucose transporter (GLUT). Foxp3 protein can bind with HIF-1?, particularly under hypoxia. In vivo ubiquination assay demonstrated that Foxp3 can decrease HIF-1? degradation in a dose-dependent manner. Knocking-down of Foxp3 expression blocks in vivo tumor growth in mice and prolongs mice's survival, which is associated with von Willebrand factor expression. Thirty-three of 145 (22.8 %) bladder tumors exhibit Foxp3 expression. Foxp3 expression is an independent predictor for disease progression in superficial bladder cancer patients (p = 0.032), associated with less number of intratumoral CD8+ lymphocyte. The metaanalysis from 2 published datasets showed Foxp3 expression is positively associated with GLUT?4, ?9, and VEGF-A, B-, D expression. This reverse post-translational regulation of HIF-1? protein by Foxp3 provides a new potential target for developing new therapeutic strategy for bladder cancer. Twit Text FOAVip Foxp3 enhances HIF-1 target gene expression in human bladder cancer through decreasing its ubiquitin-proteasomal degradation ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27557492 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27557492 #FOAvip English Wikipedia <ref>{{Cite pmid|27557492}}</ref> Foxp3 enhances HIF-1? target gene expression in human bladder cancer through decreasing its ubiquitin-proteasomal degradation #MMPMID27557492 Jou YC; Tsai YS; Lin CT; Tung CL; Shen CH; Tsai HT; Yang WH; Chang HI; Chen SY; Tzai TS Oncotarget 2016[Oct]; 7 (40): 65403-17 PMID27557492show ga Hypoxia-inducible factor-1? (HIF-1?) can control a transcriptional factor forkhead box P3 (Foxp3) protein expression in T lymphocyte differentiation through proteasome-mediated degradation. In this study, we unveil a reverse regulatory mechanism contributing to bladder cancer progression; Foxp3 expression attenuates HIF-1? degradation. We first demonstrated that Foxp3 expression positively correlates with the metastatic potential in T24 cells and can increase the expression of HIF-1?-target genes, such as vascular endothelial growth factor (VEGF) and glucose transporter (GLUT). Foxp3 protein can bind with HIF-1?, particularly under hypoxia. In vivo ubiquination assay demonstrated that Foxp3 can decrease HIF-1? degradation in a dose-dependent manner. Knocking-down of Foxp3 expression blocks in vivo tumor growth in mice and prolongs mice's survival, which is associated with von Willebrand factor expression. Thirty-three of 145 (22.8 %) bladder tumors exhibit Foxp3 expression. Foxp3 expression is an independent predictor for disease progression in superficial bladder cancer patients (p = 0.032), associated with less number of intratumoral CD8+ lymphocyte. The metaanalysis from 2 published datasets showed Foxp3 expression is positively associated with GLUT?4, ?9, and VEGF-A, B-, D expression. This reverse post-translational regulation of HIF-1? protein by Foxp3 provides a new potential target for developing new therapeutic strategy for bladder cancer. äFoxp3 enhances HIF-1? target gene expression in human bladder cancer t(epmc).pdf DeepDyve Pubget Overpricing