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10.18632/oncotarget.11333 http://scihub22266oqcxt.onion/10.18632/oncotarget.11333 C5323132!5323132!27542247     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (40): 64987-5000 Nephropedia Template TP {{tp|p=27542247|t=2016. Targeting prohibitins induces apoptosis in acute myeloid leukemia cells |pdf=|usr=}}{{27542247}} gab.com Text Targeting prohibitins induces apoptosis in acute myeloid leukemia cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27542247 #FOAvip Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins (PHBs). In this study, the pro-apoptotic effect of fluorizoline was assessed in two cell lines and 21 primary samples from patients with debut of acute myeloid leukemia (AML). Fluorizoline induced apoptosis in AML cells at concentrations in the low micromolar range. All primary samples were sensitive to fluorizoline irrespectively of patients' clinical or genetic features. In addition, fluorizoline inhibited the clonogenic capacity and induced differentiation of AML cells. Fluorizoline increased the mRNA and protein levels of the pro-apoptotic BCL-2 family member NOXA both in cell lines and primary samples analyzed. These results suggest that targeting PHBs could be a new therapeutic strategy for AML. Twit Text FOAVip Targeting prohibitins induces apoptosis in acute myeloid leukemia cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27542247 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27542247 #FOAvip English Wikipedia <ref>{{Cite pmid|27542247}}</ref> Targeting prohibitins induces apoptosis in acute myeloid leukemia cells #MMPMID27542247 Pomares H; Palmeri CM; Iglesias-Serret D; Moncunill-Massaguer C; Saura-Esteller J; Núñez-Vázquez S; Gamundi E; Arnan M; Preciado S; Albericio F; Lavilla R; Pons G; González-Barca EM; Cosialls AM; Gil J Oncotarget 2016[Oct]; 7 (40): 64987-5000 PMID27542247show ga Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins (PHBs). In this study, the pro-apoptotic effect of fluorizoline was assessed in two cell lines and 21 primary samples from patients with debut of acute myeloid leukemia (AML). Fluorizoline induced apoptosis in AML cells at concentrations in the low micromolar range. All primary samples were sensitive to fluorizoline irrespectively of patients' clinical or genetic features. In addition, fluorizoline inhibited the clonogenic capacity and induced differentiation of AML cells. Fluorizoline increased the mRNA and protein levels of the pro-apoptotic BCL-2 family member NOXA both in cell lines and primary samples analyzed. These results suggest that targeting PHBs could be a new therapeutic strategy for AML. äTargeting prohibitins induces apoptosis in acute myeloid leukemia cell(epmc).pdf DeepDyve Pubget Overpricing