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10.18632/oncotarget.11711 http://scihub22266oqcxt.onion/10.18632/oncotarget.11711 C5323120!5323120 !27588493     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27588493 &cmd=llinks): Failed to open stream: HTTP request failed! 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Ovarian hormones through Wnt signalling regulate the growth of human and mouse ovarian cancer initiating lesions |pdf=|usr=}}{{27588493 }} gab.com Text Ovarian hormones through Wnt signalling regulate the growth of human and mouse ovarian cancer initiating lesions JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27588493 #FOAvip Ovarian cancer (OC) is the most deadly gynaecological disease largely because the majority of patients are asymptomatic and diagnosed at later stages when cancer has spread to other vital organs. Therefore, the initial stages of this disease are poorly characterised. Women with BRCA1/2 mutations have a genetic predisposition for developing OC, but not all of these women develop the disease. Epidemiological findings show that lifestyle factors such as contraceptive use and pregnancy, a progesterone dominant state, decrease the risk of getting OC. How ovarian hormones modify the risk of OC is currently unclear. Our study identifies activated Wnt signalling to be a marker for precursor lesions of OC and successfully develops a mouse model that mimics the earliest events in pathogenesis of OC by constitutively activating ?catenin. Using this model and human OC cells, we show that oestrogen promotes and progesterone suppresses the growth of OC cells. Twit Text FOAVip Ovarian hormones through Wnt signalling regulate the growth of human and mouse ovarian cancer initiating lesions ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27588493 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27588493 #FOAvip English Wikipedia <ref>{{Cite pmid|27588493 }}</ref> Ovarian hormones through Wnt signalling regulate the growth of human and mouse ovarian cancer initiating lesions #MMPMID27588493 Nagendra PB ; Goad J ; Nielsen S ; Rassam L ; Lombard JM ; Nahar P ; Tanwar PS Oncotarget 2016[Oct]; 7 (40 ): 64836-64853 PMID27588493 show ga Ovarian cancer (OC) is the most deadly gynaecological disease largely because the majority of patients are asymptomatic and diagnosed at later stages when cancer has spread to other vital organs. Therefore, the initial stages of this disease are poorly characterised. Women with BRCA1/2 mutations have a genetic predisposition for developing OC, but not all of these women develop the disease. Epidemiological findings show that lifestyle factors such as contraceptive use and pregnancy, a progesterone dominant state, decrease the risk of getting OC. How ovarian hormones modify the risk of OC is currently unclear. Our study identifies activated Wnt signalling to be a marker for precursor lesions of OC and successfully develops a mouse model that mimics the earliest events in pathogenesis of OC by constitutively activating ?catenin. Using this model and human OC cells, we show that oestrogen promotes and progesterone suppresses the growth of OC cells. |*Wnt Signaling Pathway [MESH] |Adult [MESH] |Animals [MESH] |Carcinogenesis [MESH] |Disease Models, Animal [MESH] |Estrogens/*metabolism [MESH] |Female [MESH] |Humans [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Middle Aged [MESH] |Ovarian Neoplasms/*metabolism/pathology [MESH] |Progesterone/*metabolism [MESH] |Young Adult [MESH]Ovarian hormones through Wnt signalling regulate the growth of human a(epmc).pdf DeepDyve Pubget Overpricing