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10.18632/oncotarget.11622 http://scihub22266oqcxt.onion/10.18632/oncotarget.11622 C5323116!5323116 !27579617     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27579617 &cmd=llinks): Failed to open stream: HTTP request failed! 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CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts |pdf=|usr=}}{{27579617 }} gab.com Text CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27579617 #FOAvip CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis. Exploiting CD45 KO mice and lentiviral shRNA, we prove the crucial role that CD45 plays in acute myeloid leukemia (AML) development and maintenance. We discovered that CD45 does not colocalize with lipid rafts on murine and human non-transformed hematopoietic cells. Using a mouse model, we proved that CD45 positioning within lipid rafts is modified during their oncogenic transformation to AML. CD45 colocalized with lipid rafts on AML cells, which contributes to elevated GM-CSF signal intensity involved in proliferation of leukemic cells. We furthermore proved that the GM-CSF/Lyn/Stat3 pathway that contributes to growth of leukemic cells could be profoundly affected, by using a new plasma membrane disrupting agent, which rapidly delocalized CD45 away from lipid rafts. We provide evidence that this mechanism is also effective on human primary AML samples and xenograft transplantation. In conclusion, this study highlights the emerging evidence of the involvement of lipid rafts in oncogenic development of AML and the targeting of CD45 positioning among lipid rafts as a new strategy in the treatment of AML. Twit Text FOAVip CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27579617 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27579617 #FOAvip English Wikipedia <ref>{{Cite pmid|27579617 }}</ref> CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts #MMPMID27579617 Saint-Paul L ; Nguyen CH ; Buffière A ; Pais de Barros JP ; Hammann A ; Landras-Guetta C ; Filomenko R ; Chrétien ML ; Johnson P ; Bastie JN ; Delva L ; Quéré R Oncotarget 2016[Oct]; 7 (40 ): 64785-64797 PMID27579617 show ga CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis. Exploiting CD45 KO mice and lentiviral shRNA, we prove the crucial role that CD45 plays in acute myeloid leukemia (AML) development and maintenance. We discovered that CD45 does not colocalize with lipid rafts on murine and human non-transformed hematopoietic cells. Using a mouse model, we proved that CD45 positioning within lipid rafts is modified during their oncogenic transformation to AML. CD45 colocalized with lipid rafts on AML cells, which contributes to elevated GM-CSF signal intensity involved in proliferation of leukemic cells. We furthermore proved that the GM-CSF/Lyn/Stat3 pathway that contributes to growth of leukemic cells could be profoundly affected, by using a new plasma membrane disrupting agent, which rapidly delocalized CD45 away from lipid rafts. We provide evidence that this mechanism is also effective on human primary AML samples and xenograft transplantation. In conclusion, this study highlights the emerging evidence of the involvement of lipid rafts in oncogenic development of AML and the targeting of CD45 positioning among lipid rafts as a new strategy in the treatment of AML. |Animals [MESH] |Carcinogenesis/genetics [MESH] |Cell Line, Tumor [MESH] |Female [MESH] |Genetic Vectors [MESH] |Granulocyte-Macrophage Colony-Stimulating Factor/metabolism [MESH] |Hematopoiesis/genetics [MESH] |Humans [MESH] |Lentivirus/genetics [MESH] |Leukemia, Myeloid, Acute/*metabolism/pathology [MESH] |Leukocyte Common Antigens/genetics/*metabolism [MESH] |Membrane Microdomains/*metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |RNA, Small Interfering/genetics [MESH] |STAT3 Transcription Factor/metabolism [MESH] |Signal Transduction [MESH]CD45 phosphatase is crucial for human and murine acute myeloid leukemi(epmc).pdf DeepDyve Pubget Overpricing