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10.1038/ncomms14509 http://scihub22266oqcxt.onion/10.1038/ncomms14509 C5322540!5322540!28224999     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28224999|t=2017. Allograft inflammatory factor 1 is a regulator of transcytosis in M cells |pdf=|usr=}}{{28224999}} gab.com Text Allograft inflammatory factor 1 is a regulator of transcytosis in M cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28224999 #FOAvip M cells in follicle-associated epithelium (FAE) are specialized antigen-sampling cells that take up intestinal luminal antigens. Transcription factor Spi-B regulates M-cell maturation, but the molecules that promote transcytosis within M cells are not fully identified. Here we show that mouse allograft inflammatory factor 1 (Aif1) is expressed by M cells and contributes to M-cell transcytosis. FAE in Aif1?/? mice has suppressed uptake of particles and commensal bacteria, compared with wild-type mice. Translocation of Yersinia enterocolitica, but not of Salmonella enterica serovar Typhimurium, leading to the generation of antigen-specific IgA antibodies, is also diminished in Aif1-deficient mice. Although ?1 integrin, which acts as a receptor for Y. enterocolitica via invasin protein, is expressed on the apical surface membranes of M cells, its active form is rarely found in Aif1?/? mice. These findings show that Aif1 is important for bacterial and particle transcytosis in M cells. Twit Text FOAVip Allograft inflammatory factor 1 is a regulator of transcytosis in M cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28224999 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28224999 #FOAvip English Wikipedia <ref>{{Cite pmid|28224999}}</ref> Allograft inflammatory factor 1 is a regulator of transcytosis in M cells #MMPMID28224999 Kishikawa S; Sato S; Kaneto S; Uchino S; Kohsaka S; Nakamura S; Kiyono H Nat Commun 2017[]; 8 (ä): ä PMID28224999show ga M cells in follicle-associated epithelium (FAE) are specialized antigen-sampling cells that take up intestinal luminal antigens. Transcription factor Spi-B regulates M-cell maturation, but the molecules that promote transcytosis within M cells are not fully identified. Here we show that mouse allograft inflammatory factor 1 (Aif1) is expressed by M cells and contributes to M-cell transcytosis. FAE in Aif1?/? mice has suppressed uptake of particles and commensal bacteria, compared with wild-type mice. Translocation of Yersinia enterocolitica, but not of Salmonella enterica serovar Typhimurium, leading to the generation of antigen-specific IgA antibodies, is also diminished in Aif1-deficient mice. Although ?1 integrin, which acts as a receptor for Y. enterocolitica via invasin protein, is expressed on the apical surface membranes of M cells, its active form is rarely found in Aif1?/? mice. These findings show that Aif1 is important for bacterial and particle transcytosis in M cells. äAllograft inflammatory factor 1 is a regulator of transcytosis in M ce(epmc).pdf DeepDyve Pubget Overpricing