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2017 ; 34
(1
): 1-9
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A Review of Myeloablative vs Reduced Intensity/Non-Myeloablative Regimens in
Allogeneic Hematopoietic Stem Cell Transplantations
#MMPMID28251017
Atilla E
; Ataca Atilla P
; Demirer T
Balkan Med J
2017[Jan]; 34
(1
): 1-9
PMID28251017
show ga
Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is a curative
treatment option for both malignant and some benign hematological diseases.
During the last decade, many of the newer high-dose regimens in different
intensity have been developed specifically for patients with hematologic
malignancies and solid tumors. Today there are three main approaches used prior
to allogeneic transplantation: Myeloablative (MA), Reduced Intensity Conditioning
(RIC) and Non-MA (NMA) regimens. MA regimens cause irreversible cytopenia and
there is a requirement for stem cell support. Patients who receive NMA regimen
have minimal cytopenia and this type of regimen can be given without stem cell
support. RIC regimens do not fit the criteria of MA and NMA: the cytopenia is
reversible and the stem cell support is necessary. NMA/RIC for Allo-HSCT has
opened a new era for treating elderly patients and those with comorbidities. The
RIC conditioning was used for 40% of all Allo-HSCT and this trend continue to
increase. In this paper, we will review these regimens in the setting of
especially allogeneic HSCT and our aim is to describe the history, features and
impact of these conditioning regimens on specific diseases.