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2017 ; 2017
(ä): 9604570
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A Giant-Cell Lesion with Cellular Cannibalism in the Mandible: Case Report and
Review of Brown Tumors in Hyperparathyroidism
#MMPMID28280638
Azzi L
; Cimetti L
; Annoni M
; Anselmi D
; Tettamanti L
; Tagliabue A
Case Rep Dent
2017[]; 2017
(ä): 9604570
PMID28280638
show ga
A small radiolucent area in the mandible was discovered in a 58-year-old woman
with no oral complaints. The patient's history included only hypertension. The
lesion was considered as an inflammatory cyst and was enucleated. Three months
later, a CT revealed the presence of a cyst-like lesion in the mandible with thin
expanded buccal cortical plate, localized erosion, and a polylobate appearance on
the lingual aspect of the cortical plate. The histological diagnosis of the
lesion was central giant-cell granuloma (CGCG). The lesion was thoroughly
enucleated. Nevertheless, another X-ray carried out six months later revealed
multiple bilateral osteolytic areas throughout the jaw. In addition, widespread
cortical plate erosion was observed, as well as signs of root resorption and
periodontal enlargement. There was no sign of neurological involvement, although
the nerves appeared to be dislocated. After full blood chemistry analysis and
detailed collection of radiographs, the final diagnosis was brown tumors in
primary hyperparathyroidism. This case report demonstrates how dental clinicians
may be the first-line specialists who identify a complex systemic disease before
other clinicians. Finally, it highlights the role of cellular cannibalism in
predicting the clinical aggressiveness of brown tumors as well as in other
giant-cell lesions.