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10.1038/srep43259 http://scihub22266oqcxt.onion/10.1038/srep43259 C5322393!5322393 !28230187     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28230187 &cmd=llinks): Failed to open stream: HTTP request failed! 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Silencing salusin-? attenuates cardiovascular remodeling and hypertension in spontaneously hypertensive rats |pdf=|usr=}}{{28230187 }} gab.com Text Silencing salusin- attenuates cardiovascular remodeling and hypertension in spontaneously hypertensive rats JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28230187 #FOAvip Salusin-? is a bioactive peptide involved in vascular smooth muscle cell proliferation, vascular fibrosis and hypertension. The present study was designed to determine the effects of silencing salusin-? on hypertension and cardiovascular remodeling in spontaneously hypertensive rats (SHR). Thirteen-week-old male SHR and normotensive Wistar-Kyoto rats (WKY) were subjected to intravenous injection of PBS, adenoviral vectors encoding salusin-? shRNA (Ad-Sal-shRNA) or a scramble shRNA. Salusin-? levels in plasma, myocardium and mesenteric artery were increased in SHR. Silencing salusin-? had no significant effect on blood pressure in WKY, but reduced blood pressure in SHR. It reduced the ratio of left ventricle weight to body weight, cross-sectional areas of cardiocytes and perivascular fibrosis, and decreased the media thickness and the media/lumen ratio of arteries in SHR. Silencing salusin-? almost normalized plasma norepinephrine and angiotensin II levels in SHR. It prevented the upregulation of angiotensin II and AT(1) receptors, and reduced the NAD(P)H oxidase activity and superoxide anion levels in myocardium and mesenteric artery of SHR. Knockdown of salusin-? attenuated cell proliferation and fibrosis in vascular smooth muscle cells from SHR. These results indicate that silencing salusin-? attenuates hypertension and cardiovascular remodeling in SHR. Twit Text FOAVip Silencing salusin- attenuates cardiovascular remodeling and hypertension in spontaneously hypertensive rats ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28230187 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28230187 #FOAvip English Wikipedia <ref>{{Cite pmid|28230187 }}</ref> Silencing salusin-? attenuates cardiovascular remodeling and hypertension in spontaneously hypertensive rats #MMPMID28230187 Ren XS ; Ling L ; Zhou B ; Han Y ; Zhou YB ; Chen Q ; Li YH ; Kang YM ; Zhu GQ Sci Rep 2017[Feb]; 7 (ä): 43259 PMID28230187 show ga Salusin-? is a bioactive peptide involved in vascular smooth muscle cell proliferation, vascular fibrosis and hypertension. The present study was designed to determine the effects of silencing salusin-? on hypertension and cardiovascular remodeling in spontaneously hypertensive rats (SHR). Thirteen-week-old male SHR and normotensive Wistar-Kyoto rats (WKY) were subjected to intravenous injection of PBS, adenoviral vectors encoding salusin-? shRNA (Ad-Sal-shRNA) or a scramble shRNA. Salusin-? levels in plasma, myocardium and mesenteric artery were increased in SHR. Silencing salusin-? had no significant effect on blood pressure in WKY, but reduced blood pressure in SHR. It reduced the ratio of left ventricle weight to body weight, cross-sectional areas of cardiocytes and perivascular fibrosis, and decreased the media thickness and the media/lumen ratio of arteries in SHR. Silencing salusin-? almost normalized plasma norepinephrine and angiotensin II levels in SHR. It prevented the upregulation of angiotensin II and AT(1) receptors, and reduced the NAD(P)H oxidase activity and superoxide anion levels in myocardium and mesenteric artery of SHR. Knockdown of salusin-? attenuated cell proliferation and fibrosis in vascular smooth muscle cells from SHR. These results indicate that silencing salusin-? attenuates hypertension and cardiovascular remodeling in SHR. |*Gene Silencing [MESH] |*Rats, Inbred SHR [MESH] |*Vascular Remodeling [MESH] |*Ventricular Remodeling [MESH] |Animals [MESH] |Blood Pressure [MESH] |Intercellular Signaling Peptides and Proteins/*genetics [MESH] |RNA, Small Interfering/administration & dosage [MESH]Silencing salusin-? attenuates cardiovascular remodeling and hypertens(epmc).pdf DeepDyve Pubget Overpricing