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10.1038/srep43201 http://scihub22266oqcxt.onion/10.1038/srep43201 C5322336!5322336!28230086     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28230086&cmd=llinks): Failed to open stream: HTTP request failed! 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Classification of idiopathic interstitial pneumonias using anti?myxovirus resistance-protein 1 autoantibody |pdf=|usr=}}{{28230086}} gab.com Text Classification of idiopathic interstitial pneumonias using anti myxovirus resistance-protein 1 autoantibody JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28230086 #FOAvip Chronic fibrosing idiopathic interstitial pneumonia (IIP) can be divided into two main types: idiopathic pulmonary fibrosis (IPF), a steroid-resistant and progressive disease with a median survival of 2?3 years, and idiopathic non-specific interstitial pneumonia (INSIP), a steroid-sensitive and non-progressive autoimmune disease. Although the clinical courses of these two diseases differ, they may be difficult to distinguish at diagnosis. We performed a comprehensive analysis of serum autoantibodies from patients definitively diagnosed with IPF, INSIP, autoimmune pulmonary alveolar proteinosis, and sarcoidosis. We identified disease-specific autoantibodies and enriched KEGG pathways unique to each disease, and demonstrated that IPF and INSIP are serologically distinct. Furthermore, we discovered a new INSIP-specific autoantibody, anti?myxovirus resistance-1 (MX1) autoantibody. Patients positive for anti-MX1 autoantibody constituted 17.5% of all cases of chronic fibrosing IIPs. Notably, patients rarely simultaneously carried the anti-MX1 autoantibody and the anti?aminoacyl-transfer RNA synthetase autoantibody, which is common in chronic fibrosing IIPs. Because MX1 is one of the most important interferon-inducible anti-viral genes, we have not only identified a new diagnostic autoantibody of INSIP but also obtained new insight into the pathology of INSIP, which may be associated with viral infection and autoimmunity. Twit Text FOAVip Classification of idiopathic interstitial pneumonias using anti myxovirus resistance-protein 1 autoantibody ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28230086 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28230086 #FOAvip English Wikipedia <ref>{{Cite pmid|28230086}}</ref> Classification of idiopathic interstitial pneumonias using anti?myxovirus resistance-protein 1 autoantibody #MMPMID28230086 Hamano Y; Kida H; Ihara S; Murakami A; Yanagawa M; Ueda K; Honda O; Tripathi LP; Arai T; Hirose M; Hamasaki T; Yano Y; Kimura T; Kato Y; Takamatsu H; Otsuka T; Minami T; Hirata H; Inoue K; Nagatomo I; Takeda Y; Mori M; Nishikawa H; Mizuguchi K; Kijima T; Kitaichi M; Tomiyama N; Inoue Y; Kumanogoh A Sci Rep 2017[]; 7 (ä): ä PMID28230086show ga Chronic fibrosing idiopathic interstitial pneumonia (IIP) can be divided into two main types: idiopathic pulmonary fibrosis (IPF), a steroid-resistant and progressive disease with a median survival of 2?3 years, and idiopathic non-specific interstitial pneumonia (INSIP), a steroid-sensitive and non-progressive autoimmune disease. Although the clinical courses of these two diseases differ, they may be difficult to distinguish at diagnosis. We performed a comprehensive analysis of serum autoantibodies from patients definitively diagnosed with IPF, INSIP, autoimmune pulmonary alveolar proteinosis, and sarcoidosis. We identified disease-specific autoantibodies and enriched KEGG pathways unique to each disease, and demonstrated that IPF and INSIP are serologically distinct. Furthermore, we discovered a new INSIP-specific autoantibody, anti?myxovirus resistance-1 (MX1) autoantibody. Patients positive for anti-MX1 autoantibody constituted 17.5% of all cases of chronic fibrosing IIPs. Notably, patients rarely simultaneously carried the anti-MX1 autoantibody and the anti?aminoacyl-transfer RNA synthetase autoantibody, which is common in chronic fibrosing IIPs. Because MX1 is one of the most important interferon-inducible anti-viral genes, we have not only identified a new diagnostic autoantibody of INSIP but also obtained new insight into the pathology of INSIP, which may be associated with viral infection and autoimmunity. äClassification of idiopathic interstitial pneumonias using anti?myxovi(epmc).pdf DeepDyve Pubget Overpricing