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10.3389/fimmu.2017.00180 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.00180 C5322283!5322283!28280495     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28280495&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28280495|t=2017. Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis |pdf=|usr=}}{{28280495}} gab.com Text Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28280495 #FOAvip Tuberculosis of the central nervous system (CNS-TB) is a devastating complication of tuberculosis, and tumor necrosis factor (TNF) is crucial for innate immunity and controlling the infection. TNF is produced by many cell types upon activation, in particularly the myeloid and T cells during neuroinflammation. Here we used mice with TNF ablation targeted to myeloid and T cell (MT-TNF?/?) to assess the contribution of myeloid and T cell-derived TNF in immune responses during CNS-TB. These mice exhibited impaired innate immunity and high susceptibility to cerebral Mycobacterium tuberculosis infection, a similar phenotype to complete TNF-deficient mice. Further, MT-TNF?/? mice were not able to control T cell responses and cytokine/chemokine production. Thus, our data suggested that collective TNF production by both myeloid and T cells are required to provide overall protective immunity against CNS-TB infection. Twit Text FOAVip Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28280495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28280495 #FOAvip English Wikipedia <ref>{{Cite pmid|28280495}}</ref> Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis #MMPMID28280495 Hsu NJ; Francisco NM; Keeton R; Allie N; Quesniaux VFJ; Ryffel B; Jacobs M Front Immunol 2017[]; 8 (ä): ä PMID28280495show ga Tuberculosis of the central nervous system (CNS-TB) is a devastating complication of tuberculosis, and tumor necrosis factor (TNF) is crucial for innate immunity and controlling the infection. TNF is produced by many cell types upon activation, in particularly the myeloid and T cells during neuroinflammation. Here we used mice with TNF ablation targeted to myeloid and T cell (MT-TNF?/?) to assess the contribution of myeloid and T cell-derived TNF in immune responses during CNS-TB. These mice exhibited impaired innate immunity and high susceptibility to cerebral Mycobacterium tuberculosis infection, a similar phenotype to complete TNF-deficient mice. Further, MT-TNF?/? mice were not able to control T cell responses and cytokine/chemokine production. Thus, our data suggested that collective TNF production by both myeloid and T cells are required to provide overall protective immunity against CNS-TB infection. äMyeloid and T Cell-Derived TNF Protects against Central Nervous System(epmc).pdf DeepDyve Pubget Overpricing