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10.4049/jimmunol.1600764 http://scihub22266oqcxt.onion/10.4049/jimmunol.1600764 C5321846!5321846!28108559     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2017 ; 198 (5): 2017-27 Nephropedia Template TP {{tp|p=28108559|t=2017. Antigen processing in the ER is monitored by semi-invariant ?? TCRs specific for a conserved peptide-Qa-1b MHC Ib ligand1 |pdf=|usr=}}{{28108559}} gab.com Text Antigen processing in the ER is monitored by semi-invariant TCRs specific for a conserved peptide-Qa-1b MHC Ib ligand1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28108559 #FOAvip Antigen processing in the endoplasmic reticulum (ER) by ERAAP, the ER aminopeptidase associated with antigen processing is central to presentation of a normal peptide-MHC class I repertoire. Alternations in ERAAP function cause dramatic changes in the MHC I presented peptides which elicit potent immune responses. An unusual subset of CD8+ T cells monitor normal antigen processing by responding to a highly conserved FL9 peptide that is presented by Qa-1b, a non-classical MHC Ib molecule (QFL) in ERAAP-deficient cells. To understand the structural basis for recognition of the conserved ligand, we analyzed the ?? TCRs of QFL-specific T cells. Individual cells in normal wild-type and TCR ? transgenic mice were assessed for QFL-specific TCR ?-and ?-chains. The QFL-specific cells expressed a predominant semi-invariant TCR generated by DNA rearrangement of TRAV9d-3-TRAJ21 alpha and TRBV5-TRBD1-TRBJ2-7 beta chain gene segments. Further, the CDR3 regions of the ? as well as ? chains were required for QFL ligand recognition. Thus, the ?? TCRs used to recognize the peptide-Qa-1 ligand presented by ERAAP-deficient cells are semi-invariant and likely reflect conserved mechanism for monitoring the fidelity of antigen processing in the ER. Twit Text FOAVip Antigen processing in the ER is monitored by semi-invariant TCRs specific for a conserved peptide-Qa-1b MHC Ib ligand1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28108559 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28108559 #FOAvip English Wikipedia <ref>{{Cite pmid|28108559}}</ref> Antigen processing in the ER is monitored by semi-invariant ?? TCRs specific for a conserved peptide-Qa-1b MHC Ib ligand1 #MMPMID28108559 Guan J; Yang SJ; Gonzalez F; Yin Y; Shastri N J Immunol 2017[Mar]; 198 (5): 2017-27 PMID28108559show ga Antigen processing in the endoplasmic reticulum (ER) by ERAAP, the ER aminopeptidase associated with antigen processing is central to presentation of a normal peptide-MHC class I repertoire. Alternations in ERAAP function cause dramatic changes in the MHC I presented peptides which elicit potent immune responses. An unusual subset of CD8+ T cells monitor normal antigen processing by responding to a highly conserved FL9 peptide that is presented by Qa-1b, a non-classical MHC Ib molecule (QFL) in ERAAP-deficient cells. To understand the structural basis for recognition of the conserved ligand, we analyzed the ?? TCRs of QFL-specific T cells. Individual cells in normal wild-type and TCR ? transgenic mice were assessed for QFL-specific TCR ?-and ?-chains. The QFL-specific cells expressed a predominant semi-invariant TCR generated by DNA rearrangement of TRAV9d-3-TRAJ21 alpha and TRBV5-TRBD1-TRBJ2-7 beta chain gene segments. Further, the CDR3 regions of the ? as well as ? chains were required for QFL ligand recognition. Thus, the ?? TCRs used to recognize the peptide-Qa-1 ligand presented by ERAAP-deficient cells are semi-invariant and likely reflect conserved mechanism for monitoring the fidelity of antigen processing in the ER. äAntigen processing in the ER is monitored by semi-invariant ?? 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