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10.4049/jimmunol.1600764 http://scihub22266oqcxt.onion/10.4049/jimmunol.1600764 C5321846!5321846 !28108559     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28108559 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2017 ; 198 (5 ): 2017-2027 Nephropedia Template TP {{tp|p=28108559 |t=2017. Antigen Processing in the Endoplasmic Reticulum Is Monitored by Semi-Invariant ?? TCRs Specific for a Conserved Peptide-Qa-1(b) MHC Class Ib Ligand |pdf=|usr=}}{{28108559 }} gab.com Text Antigen Processing in the Endoplasmic Reticulum Is Monitored by Semi-Invariant TCRs Specific for a Conserved Peptide-Qa-1(b) MHC Class Ib Ligand JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28108559 #FOAvip Ag processing in the endoplasmic reticulum (ER) by the ER aminopeptidase associated with Ag processing (ERAAP) is central to presentation of a normal peptide-MHC class I (MHC I) repertoire. Alternations in ERAAP function cause dramatic changes in the MHC I-presented peptides, which elicit potent immune responses. An unusual subset of CD8(+) T cells monitor normal Ag processing by responding to a highly conserved FL9 peptide that is presented by Qa-1(b), a nonclassical MHC Ib molecule (QFL) in ERAAP-deficient cells. To understand the structural basis for recognition of the conserved ligand, we analyzed the ?? TCRs of QFL-specific T cells. Individual cells in normal wild-type and TCR?-transgenic mice were assessed for QFL-specific TCR ?- and ?-chains. The QFL-specific cells expressed a predominant semi-invariant TCR generated by DNA rearrangement of TRAV9d-3-TRAJ21 ?-chain and TRBV5-TRBD1-TRBJ2-7 ?-chain gene segments. Furthermore, the CDR3 regions of the ?- as well as ?-chains were required for QFL ligand recognition. Thus, the ?? TCRs used to recognize the peptide-Qa-1 ligand presented by ERAAP-deficient cells are semi-invariant and likely reflect a conserved mechanism for monitoring the fidelity of Ag processing in the ER. Twit Text FOAVip Antigen Processing in the Endoplasmic Reticulum Is Monitored by Semi-Invariant TCRs Specific for a Conserved Peptide-Qa-1(b) MHC Class Ib Ligand ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28108559 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28108559 #FOAvip English Wikipedia <ref>{{Cite pmid|28108559 }}</ref> Antigen Processing in the Endoplasmic Reticulum Is Monitored by Semi-Invariant ?? TCRs Specific for a Conserved Peptide-Qa-1(b) MHC Class Ib Ligand #MMPMID28108559 Guan J ; Yang SJ ; Gonzalez F ; Yin Y ; Shastri N J Immunol 2017[Mar]; 198 (5 ): 2017-2027 PMID28108559 show ga Ag processing in the endoplasmic reticulum (ER) by the ER aminopeptidase associated with Ag processing (ERAAP) is central to presentation of a normal peptide-MHC class I (MHC I) repertoire. Alternations in ERAAP function cause dramatic changes in the MHC I-presented peptides, which elicit potent immune responses. An unusual subset of CD8(+) T cells monitor normal Ag processing by responding to a highly conserved FL9 peptide that is presented by Qa-1(b), a nonclassical MHC Ib molecule (QFL) in ERAAP-deficient cells. To understand the structural basis for recognition of the conserved ligand, we analyzed the ?? TCRs of QFL-specific T cells. Individual cells in normal wild-type and TCR?-transgenic mice were assessed for QFL-specific TCR ?- and ?-chains. The QFL-specific cells expressed a predominant semi-invariant TCR generated by DNA rearrangement of TRAV9d-3-TRAJ21 ?-chain and TRBV5-TRBD1-TRBJ2-7 ?-chain gene segments. Furthermore, the CDR3 regions of the ?- as well as ?-chains were required for QFL ligand recognition. Thus, the ?? TCRs used to recognize the peptide-Qa-1 ligand presented by ERAAP-deficient cells are semi-invariant and likely reflect a conserved mechanism for monitoring the fidelity of Ag processing in the ER. |*Antigen Presentation [MESH] |Animals [MESH] |Antigens/metabolism [MESH] |CD8-Positive T-Lymphocytes/*immunology [MESH] |Cells, Cultured [MESH] |Conserved Sequence [MESH] |Endoplasmic Reticulum/*metabolism [MESH] |Genetic Variation [MESH] |Histocompatibility Antigens Class I/metabolism [MESH] |Leucyl Aminopeptidase/genetics/*metabolism [MESH] |Lymphocyte Activation [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Peptides/metabolism [MESH] |Receptors, Antigen, T-Cell, alpha-beta/genetics/*metabolism [MESH]Antigen Processing in the Endoplasmic Reticulum Is Monitored by Semi-I(epmc).pdf DeepDyve Pubget Overpricing