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10.4049/jimmunol.1501145 http://scihub22266oqcxt.onion/10.4049/jimmunol.1501145 C5321845!5321845 !28093526     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28093526 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2017 ; 198 (5 ): 1846-1854 Nephropedia Template TP {{tp|p=28093526 |t=2017. Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Fas(lpr) Mice |pdf=|usr=}}{{28093526 }} gab.com Text Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Fas(lpr) Mice JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28093526 #FOAvip Cysteinyl cathepsin K (CatK) is expressed in osteoclasts to mediate bone resorption, but is also inducible under inflammatory conditions. Fas(lpr) mice on a C57BL/6 background develop spontaneous systemic lupus erythematosus-like manifestations. Although normal mouse kidneys expressed negligible CatK, those from Fas(lpr) mice showed elevated CatK expression in the glomeruli and tubulointerstitial space. Fas(lpr) mice also showed elevated serum CatK levels. CatK deficiency in Fas(lpr) mice reduced all tested kidney pathologies, including glomerulus and tubulointerstitial scores, glomerulus complement C3 and IgG deposition, chemokine expression and macrophage infiltration, and serum autoantibodies. CatK contributed to Fas(lpr) mouse autoimmunity and pathology in part by its activity in TLR-7 proteolytic processing and consequent regulatory T (Treg) cell biology. Elevated TLR7 expression and proteolytic processing in Fas(lpr) mouse kidneys and Tregs showed significantly reduced levels in CatK-deficient mice, leading to increased spleen and kidney Treg content. Purified CD4(+)CD25(high)Foxp3(+) Tregs from CatK-deficient mice doubled their immunosuppressive activity against T effector cells, compared with those from CatK-sufficient mice. In Fas(lpr) mice, repopulation of purified Tregs from CatK-sufficient mice reduced spleen sizes, autoantibody titers, and glomerulus C3 and IgG deposition, and increased splenic and kidney Treg contents. Tregs from CatK-deficient mice had significantly more potency than CatK-sufficient Tregs in reducing spleen sizes, serum autoantibody titers, and glomerulus C3 deposition, and in increasing splenic and kidney Treg content. This study established a possible role of CatK in TLR7 proteolytic activation, Treg immunosuppressive activity, and lupus autoimmunity and pathology. Twit Text FOAVip Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Fas(lpr) Mice ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28093526 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28093526 #FOAvip English Wikipedia <ref>{{Cite pmid|28093526 }}</ref> Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Fas(lpr) Mice #MMPMID28093526 Zhou Y ; Chen H ; Liu L ; Yu X ; Sukhova GK ; Yang M ; Kyttaris VC ; Stillman IE ; Gelb B ; Libby P ; Tsokos GC ; Shi GP J Immunol 2017[Mar]; 198 (5 ): 1846-1854 PMID28093526 show ga Cysteinyl cathepsin K (CatK) is expressed in osteoclasts to mediate bone resorption, but is also inducible under inflammatory conditions. Fas(lpr) mice on a C57BL/6 background develop spontaneous systemic lupus erythematosus-like manifestations. Although normal mouse kidneys expressed negligible CatK, those from Fas(lpr) mice showed elevated CatK expression in the glomeruli and tubulointerstitial space. Fas(lpr) mice also showed elevated serum CatK levels. CatK deficiency in Fas(lpr) mice reduced all tested kidney pathologies, including glomerulus and tubulointerstitial scores, glomerulus complement C3 and IgG deposition, chemokine expression and macrophage infiltration, and serum autoantibodies. CatK contributed to Fas(lpr) mouse autoimmunity and pathology in part by its activity in TLR-7 proteolytic processing and consequent regulatory T (Treg) cell biology. Elevated TLR7 expression and proteolytic processing in Fas(lpr) mouse kidneys and Tregs showed significantly reduced levels in CatK-deficient mice, leading to increased spleen and kidney Treg content. Purified CD4(+)CD25(high)Foxp3(+) Tregs from CatK-deficient mice doubled their immunosuppressive activity against T effector cells, compared with those from CatK-sufficient mice. In Fas(lpr) mice, repopulation of purified Tregs from CatK-sufficient mice reduced spleen sizes, autoantibody titers, and glomerulus C3 and IgG deposition, and increased splenic and kidney Treg contents. Tregs from CatK-deficient mice had significantly more potency than CatK-sufficient Tregs in reducing spleen sizes, serum autoantibody titers, and glomerulus C3 deposition, and in increasing splenic and kidney Treg content. This study established a possible role of CatK in TLR7 proteolytic activation, Treg immunosuppressive activity, and lupus autoimmunity and pathology. |Animals [MESH] |Autoimmunity [MESH] |Cathepsin K/blood/*deficiency/genetics/*physiology [MESH] |Complement C3/immunology [MESH] |Glomerulonephritis/immunology [MESH] |Immunoglobulin G/immunology [MESH] |Kidney/immunology/physiopathology [MESH] |Lupus Erythematosus, Systemic/*immunology/*physiopathology [MESH] |Lupus Nephritis/immunology [MESH] |Membrane Glycoproteins/genetics/immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Inbred MRL lpr [MESH] |Spleen/immunology/physiopathology [MESH] |T-Lymphocytes, Regulatory/immunology [MESH] |Toll-Like Receptor 7/genetics/immunology [MESH]Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like (epmc).pdf DeepDyve Pubget Overpricing