Developmental pathways in lung regeneration #MMPMID27957616
Stabler CT; Morrisey EE
Cell Tissue Res 2017[Mar]; 367 (3): 677-85 PMID27957616show ga
The key processes of lung development have been elucidated in the past several decades, helping to identify and characterize the resident progenitor cells that ultimately generate the mature organ. The adult lung is a complex organ consisting of scores of different cell lineages that are remarkably quiescent in the absence of injury. Despite low cellular turnover, the lung can respond quickly and dramatically to acute damage when spatially restricted stem and progenitor cells re-enter the cell cycle and differentiate to promote repair. The findings from lung developmental biology are now being used to examine the mechanisms that underlie lung regeneration. The use of in vitro models such as pluripotent stem cells and new methods of gene editing have provided models for understanding lung disease, exploring the mechanisms of lung regeneration, and have raised the prospect of correcting lung dysfunction. We will outline how basic studies into lung developmental biology are now being applied to lung regeneration, opening up new avenues of research that may ultimately be harnessed for treatments of lung disease.
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Cell+Tissue+Res 2017 ; 367 (3): 677-85
